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Andrew J. Long
Researcher at Genetics Institute, Inc.
Publications - 21
Citations - 8313
Andrew J. Long is an academic researcher from Genetics Institute, Inc.. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 11, co-authored 19 publications receiving 7329 citations. Previous affiliations of Andrew J. Long include Osaka University.
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Journal ArticleDOI
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Gordon J. Freeman,Andrew J. Long,Yoshiko Iwai,Karen Bourque,Tatyana Chernova,Hiroyuki Nishimura,Lori Fitz,Nelly Malenkovich,Taku Okazaki,Michael C. Byrne,Heidi F. Horton,Lynette A. Fouser,Laura L. Carter,Vincent Ling,Michael R Bowman,Beatriz M. Carreno,Mary Collins,Clive Wood,Tasuku Honjo +18 more
TL;DR: It is reported here that the ligand of PD-1 (PD-L1), an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells, is a member of the B7 gene family.
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Yvette Latchman,Clive Wood,Tatyana Chernova,Divya Chaudhary,Madhuri Borde,Irene Chernova,Yoshiko Iwai,Andrew J. Long,Julia A. Brown,Raquel A. Nunes,Edward A. Greenfield,Karen Bourque,Vassiliki A. Boussiotis,Laura L. Carter,Beatriz M. Carreno,Nelly Malenkovich,Hiroyuki Nishimura,Taku Okazaki,Tasuku Honjo,Arlene H. Sharpe,Gordon J. Freeman +20 more
TL;DR: These studies show overlapping functions of PD-L1 andPD-L2 and indicate a key role for the PD- L–PD-1 pathway in regulating T cell responses.
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An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment
Spencer Liang,Andrew J. Long,Frann Bennett,Matthew J. Whitters,Riyez Karim,Mary Collins,Samuel J. Goldman,Kyriaki Dunussi-Joannopoulos,Cara M. M. Williams,Jill F. Wright,Lynette A. Fouser +10 more
TL;DR: The data elucidate the regulation of IL-17F/A heterodimer expression by Th17 cells and demonstrate an in vivo function for this cytokine in airway neutrophilia.
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In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
Julie M. Parmentier,Jeff Voss,Candace Graff,Annette Schwartz,Maria A. Argiriadi,Michael M. Friedman,Heidi S. Camp,Robert J. Padley,Jonathan S. George,Deborah Hyland,Matthew Rosebraugh,Neil Wishart,L. Olson,Andrew J. Long +13 more
TL;DR: The data presented here highlight the JAK1 selectivity of upadacitinib and supports its use as an effective therapy for the treatment of RA with the potential for an improved benefit:risk profile.
Journal ArticleDOI
A role for CD9 molecules in T cell activation.
Xu-Guang Tai,Yumi Yashiro,R Abe,Kazuhito Toyo-oka,C R Wood,J Morris,Andrew J. Long,Shiro Ono,Masayoshi Kobayashi,Toshiyuki Hamaoka,S Neben,Hiromi Fujiwara +11 more
TL;DR: Results indicate that CD9 serves as a molecule on T cells that can deliver a potent CD28- independent costimulatory signal.