Debra Zack

TL;DR: The safety profile of AMG 108 SC and IV was comparable with placebo in patients with OA of the knee; however, minimal, if any, clinical benefit was observed.

TL;DR: Comparison of health-related quality of life (HRQoL) before and after treatment with etanercept in patients with moderate to severe rheumatoid arthritis, psoriatic arthritis and psoriasis using spydergram representations found patients with RA, PsA and Psoriasis demonstrated unique HRZoL profiles at baseline.

TL;DR: Women had a higher burden of disease and less improvement in AS outcome measures compared with men; this was observed despite women having a later disease onset of shorter duration; the mechanism behind this observation is unclear.

TL;DR: RANKL protein was increased in rat joint extracts and serum at the earliest stages of arthritis, suggesting that RANKL is both a marker and mediator of bone loss in arthritis.

TL;DR: All RMIA are driven by overactivity of proinflammatory pathways, but the dominant molecules differ among the models, especially when the agent is a specific cytokine inhibitor.