Journal ArticleDOI
Female patients with ankylosing spondylitis: analysis of the impact of gender across treatment studies
TLDR
Women had a higher burden of disease and less improvement in AS outcome measures compared with men; this was observed despite women having a later disease onset of shorter duration; the mechanism behind this observation is unclear.Abstract:
Objectives To examine the impact (if any) of gender on the clinical, functional and patient-reported outcomes of treatment using data pooled from four controlled clinical trials. Methods Study data were pooled from four clinical control trials in which 1283 adult patients with active ankylosing spondylitis (AS) were treated with etanercept, sulfasalazine or placebo. Patients were stratified by gender and analysed for differences/similarities in baseline demographics, disease characteristics, and efficacy in AS outcome measures and safety and discontinuation rates after 12 weeks of therapy. Results Significant baseline differences were observed between 326 female patients compared with 957 male patients. Female patients had an older mean age of disease onset (35.0 vs 31.2 years; p Conclusions Women had a higher burden of disease and less improvement in AS outcome measures compared with men. This was observed despite women having a later disease onset of shorter duration; the mechanism behind this observation is unclear. Additional research is necessary to better understand female patients with AS and the burden of disease in this population.read more
Citations
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Journal ArticleDOI
Gender Differences in Axial Spondyloarthritis: Women Are Not So Lucky
TL;DR: Despite the fact that men with axial SpA have a worse radiologic prognosis, women have a high disease burden, in part because they have a longer delay in diagnosis, higher disease activity, and significantly less responsiveness to treatment with TNFi.
Journal ArticleDOI
Sexual Dimorphism in the Th17 Signature of Ankylosing Spondylitis.
Eric Gracey,Yuchen Yao,Blerta Green,Zoya Qaiyum,Yuriy Baglaenko,Aifeng Lin,Ammepa Anton,Renise Ayearst,Paul M. Yip,Robert D. Inman +9 more
TL;DR: To identify an immunologic basis for the male sex bias in ankylosing spondylitis, the objective was to establish an experimental procedure and show direct correlates with disease progression and disease progression in men and women.
Journal ArticleDOI
Gender-attributable differences in outcome of ankylosing spondylitis: long-term results from the Outcome in Ankylosing Spondylitis International Study
Casper Webers,Ivette Essers,Sofia Ramiro,Carmen Stolwijk,Robert Landewé,Désirée van der Heijde,Filip Van den Bosch,Maxime Dougados,Astrid van Tubergen,Astrid van Tubergen +9 more
TL;DR: No gender-attributable differences in disease activity or physical function over time were found, however, radiographic damage was more severe in males, and males had a better QoL over time.
Journal ArticleDOI
Patient Burden of Axial Spondyloarthritis.
Vibeke Strand,Jasvinder A. Singh +1 more
TL;DR: There remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with Ax spondyloarthritis, and new biologic agents, such as those targeting the interleukin 17–interleuk in 23 axis, have promising efficacy and may improve HRZoL for patients withAxSpA.
Journal ArticleDOI
Gender differences among patients with primary ankylosing spondylitis and spondylitis associated with psoriasis and inflammatory bowel disease in an iberoamerican spondyloarthritis cohort.
Margarita Landi,Hernan Maldonado-Ficco,Rodolfo Perez-Alamino,José A. Maldonado-Cocco,Gustavo Citera,Pablo Arturi,Percival D. Sampaio-Barros,Diana Elsa Flores Alvarado,Rubén Burgos-Vargas,Elena Santos,Daniel Palleiro,Miguel A Gutiérrez,Elsa Vieyra-Sousa,Fernando Pimentel-Santos,Sergio Paira,Alberto Berman,Claudia Vera Barrezueta,Janitzia Vázquez-Mellado,Eduardo Collantes-Estevez +18 more
TL;DR: Overall, male patients were significantly younger, had longer diagnostic delay, lower disease activity, worse spinal mobility, better quality of life, and more severe radiologic damage than women, suggesting that the phenotype of SpA differs between genders.
References
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Journal ArticleDOI
Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria.
TL;DR: The study showed the clinical history screening test for AS to be moderately sensitive, but it might be better in clinical practice, and substitution of the Rome pain criterion for the New York pain criterion is proposed.
Journal ArticleDOI
2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis
Jürgen Braun,R. van den Berg,Xenofon Baraliakos,H. Boehm,Ruben Burgos-Vargas,Eduardo Collantes-Estevez,B. Dijkmans,Paul Emery,Muhammad Asim Khan,Karel Pavelka +9 more
TL;DR: The ASAS/EULAR recommendations on the management of ankylo sing spondylitis (AS) are based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010 as mentioned in this paper.
2010 Update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis
Jürgen Braun,R. van den Berg,Xenofon Baraliakos,H. Boehm,Ruben Burgos-Vargas,Eduardo Collantes-Estevez,Hanne Dagfinrud,B. Dijkmans,Maxime Dougados,Paul Emery,P. Geher,Mohammed Hammoudeh,Robert D. Inman,Merryn Jongkees,Muhammad Asim Khan,Uta Kiltz,Tore K Kvien,Marjatta Leirisalo-Repo,Walter P. Maksymowych,I. Olivieri,Karel Pavelka,Joachim Sieper,Ewa Stanislawska-Biernat,D. Wendling,Salih Ozgocmen,C. Van Drogen,B.J. van Royen,D. van der Heijde +27 more
TL;DR: This first update of the ASAS/EULAR recommendations on the management of ankylosing spondylitis is based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010.
Journal ArticleDOI
Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled trial.
John C. Davis,Désirée van der Heijde,Jürgen Braun,Maxime Dougados,John J. Cush,Daniel O. Clegg,Alan Kivitz,Roy Fleischmann,Robert D. Inman,Wayne Tsuji +9 more
TL;DR: Etanercept is a highly effective and well tolerated treatment in patients with active ankylosing spondylitis and the safety profile of etanercept was similar to that reported in studies of patients with rheumatoid arthritis or psoriatic arthritis.
Journal Article
Disability and handicap in rheumatoid arthritis and ankylosing spondylitis--results from the German rheumatological database. German Collaborative Arthritis Centers.
TL;DR: Age and sex matched groups of patients with RA and AS in tertiary rheumatological care show similar amounts of disability, pain, and reduction in well being, therefore, the offer of comprehensive care and pain management to both groups should be comparable.
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