D
Deena Wassenberg
Researcher at University of Minnesota
Publications - 21
Citations - 1231
Deena Wassenberg is an academic researcher from University of Minnesota. The author has contributed to research in topics: Aryl hydrocarbon receptor & Benzo(a)pyrene. The author has an hindex of 13, co-authored 21 publications receiving 1121 citations. Previous affiliations of Deena Wassenberg include Duke University.
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Journal ArticleDOI
The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.
Sonya M. Billiard,Alicia R. Timme-Laragy,Deena Wassenberg,Crystal J. Cockman,Richard T. Di Giulio +4 more
TL;DR: It is demonstrated here that coexposure of zebrafish embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha- naphth oflav one (ANF) significantly enhanced toxicity above that observed for single-compound exposures, and suggested that mechanisms underlying developmental toxicity of PAH -type A HR agonists are different from those of pHAHs.
Journal ArticleDOI
Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus
TL;DR: Additive models of PAH embryotoxicity for environmental PAH mixtures that contain both AHR agonists and CYP1A inhibitors are called into question.
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Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment.
Sonya M. Billiard,Sonya M. Billiard,Joel N. Meyer,Deena Wassenberg,Peter V. Hodson,Richard T. Di Giulio,Richard T. Di Giulio +6 more
TL;DR: The current knowledge of teratogenicity caused by single PAH compounds and by mixtures is discussed and the importance of these latest findings for adequately assessing risk of PAHs to humans and wildlife is discussed.
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In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene.
Kristine L. Willett,Deena Wassenberg,Laila A. Lienesch,William Reichert,Richard T. Di Giulio +4 more
TL;DR: CYP1A immunoreactive protein was significantly decreased in vivo by FL cotreatment, indicating that FL may inhibit EROD activity by down-regulating the CYP1A protein.
Journal ArticleDOI
Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities.
TL;DR: The co‐occurrence of CB and DBT with PAH‐type AHR inducers in contaminated ecosystems may increase the toxicity ofPAH‐ type AHR agonists in these settings and may need to be considered when estimating the embryotoxicity of PAH mixtures.