D
Deepika Dhawan
Researcher at Purdue University
Publications - 44
Citations - 1064
Deepika Dhawan is an academic researcher from Purdue University. The author has contributed to research in topics: Cancer & Bladder cancer. The author has an hindex of 17, co-authored 38 publications receiving 828 citations. Previous affiliations of Deepika Dhawan include University of Indianapolis & All India Institute of Medical Sciences.
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Journal ArticleDOI
Urinary Bladder Cancer in Dogs, a Naturally Occurring Model for Cancer Biology and Drug Development
Deborah W. Knapp,José A. Ramos-Vara,George E. Moore,Deepika Dhawan,Patty L. Bonney,Kirsten E Young +5 more
TL;DR: Results of cellular and molecular studies and -omics analyses in dogs are expected to lead to improved detection of TCC and preneoplastic lesions, earlier intervention, better prediction of patient outcome, and more effective TCC management overall.
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Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer—Evidence for a Relevant Model System and Urine-Based Diagnostic Test
Brennan Decker,Brennan Decker,Heidi G. Parker,Deepika Dhawan,Erika M. Kwon,Eric Karlins,Brian W. Davis,José A. Ramos-Vara,Patty L. Bonney,Elizabeth A. McNiel,Deborah W. Knapp,Elaine A. Ostrander +11 more
TL;DR: This study demonstrates the activating BRAF mutation (V600E), which is found in multiple human cancers, is a driver of canine InvTCC, and highlights a urine-based test for quick diagnosis.
Journal ArticleDOI
Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effects
Sulma I. Mohammed,Deepika Dhawan,Shaji Abraham,Paul W. Snyder,David J. Waters,Bruce A. Craig,Ming Lu,Lan Wu,Rong Zheng,Jane C. Stewart,Deborah W. Knapp +10 more
TL;DR: Standard in vitro assays were not useful in predicting COX inhibitor antitumor effects observed in vivo, and Athymic mice bearing TCC xenografts provide a useful in vivo system forCOX inhibitor studies.
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Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer.
Deepika Dhawan,Melissa Paoloni,Shweta Shukradas,Dipanwita Roy Choudhury,Bruce A. Craig,José A. Ramos-Vara,Noah M. Hahn,Patty L. Bonney,Chand Khanna,Deborah W. Knapp +9 more
TL;DR: The similarities in gene expression patterns between dogs and humans add considerably to the value of naturally-occurring canine iUC as a relevant and much needed animal model for human iUC.
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Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer
TL;DR: Eight established cell lines derived from canine InvTCC can be used for comparative bladder cancer research and to evaluate new therapy approaches in vitro prior to in vivo testing.