Showing papers by "Delbert Robinson published in 2019"

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Journal Article•DOI•

Schizophrenia Polygenic Risk Score as a Predictor of Antipsychotic Efficacy in First-Episode Psychosis

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Jian-Ping Zhang¹, Delbert Robinson, Jin Yu², Juan A. Gallego³, W. Wolfgang Fleischhacker, René S. Kahn⁴, Benedicto Crespo-Facorro⁵, Javier Vázquez-Bourgon, John M. Kane, Anil K. Malhotra, Todd Lencz - Show less +7 more•Institutions (5)

Hofstra University¹, The Feinstein Institute for Medical Research², Cornell University³, Icahn School of Medicine at Mount Sinai⁴, University of Cantabria⁵

01 Jan 2019-American Journal of Psychiatry

TL;DR: Patients with higher polygenic risk scores for schizophrenia tended to have less improvement with antipsychotic drug treatment, and PRS burden may have potential utility as a prognostic biomarker.

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Abstract: Objective:Pharmacogenomic studies of antipsychotics have typically examined effects of individual polymorphisms. By contrast, polygenic risk scores (PRSs) derived from genome-wide association studi...

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109 citations