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Denethi Wijegunawardana
Researcher at Ohio State University
Publications - 3
Citations - 20
Denethi Wijegunawardana is an academic researcher from Ohio State University. The author has contributed to research in topics: Heterogeneous nuclear ribonucleoprotein & Medicine. The author has an hindex of 1, co-authored 1 publications receiving 14 citations.
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Journal ArticleDOI
MD-Miner: a network-based approach for personalized drug repositioning.
Haoyang Wu,Elise Miller,Elise Miller,Denethi Wijegunawardana,Kelly Regan,Philip R. O. Payne,Fuhai Li +6 more
TL;DR: The MD-Miner method was evaluated and it was shown that it significantly improved the success rate of discovering effective drugs compared with the random selection, and could provide insight into potential mechanisms of action in terms of signaling transduction networks.
Journal ArticleDOI
Sequence Determinants of TDP-43 Ribonucleoprotein Condensate Formation and Axonal Transport in Neurons
TL;DR: It is demonstrated that the conserved α-helical domain, phenylalanine residues within LARKS and RGG motif are key determinants of TDP-43 RNP transport, suggesting they may mediate efficient recruitment of motors and adaptor proteins.
Posted ContentDOI
Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43, drive ribonucleoprotein condensate transport dysfunction and suppress local translation
TL;DR: In this article , the authors used live-cell confocal imaging, photobleaching and translation reporter assays to study the localization, transport dynamics and mRNA regulatory functions of TDP-43/Ataxin-2 in rodent primary cortical neurons.