Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.

Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways.

Background Scutellarin (SCU), a flavonoid isolated from Erigeron breviscapus (Vant.) Hand.-Mazz., increases autophagy and apoptosis in the adenocarcinoma A549 cell line, which is resistant to cisplatin. However, whether SCU alone has antitumor activity against non-small cell lung cancer (NSCLC) is unknown. Methods Cell Counting Kit-8, flow cytometry, colony formation, Hoechst 33258 staining, and Western blot analyses were used to examine the proliferation and apoptosis of A549 cells treated with SCU and the possible molecular mechanisms. Results The cell viability assay indicated that SCU markedly suppressed the proliferation of A549 cells in concentration and time-dependent manners. SCU caused significant G0/G1 phase arrest and apoptosis, as evidenced by flow cytometric analyses, Hoechst 33258 staining, and Western blot analyses of cyclin D1, cyclin E, BCL-2, cleaved-caspase-3, and BAX. Furthermore, SCU treatment reduced the level of pan-AKT, phosphorylated (p)-mTOR, mTOR, BCL-XL, STAT3, and p-STAT3, and increased the level of 4EBP1. Conclusions SCU can suppress proliferation and promote apoptosis in A549 cells through AKT/mTOR/4EBP1 and STAT3 pathways. This suggests that SCU may be developed into a promising antitumor agent for treating NSCLC.

Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways

Scutellarin inhibits the invasive potential of malignant melanoma cells through the suppression epithelial-mesenchymal transition and angiogenesis via the PI3K/Akt/mTOR signaling pathway.

Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.

Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN

The invention discloses a compound environment-friendly plasticizer for polyvinyl chloride resin. The plasticizer mainly comprises a di(C4-C20) alkylcyclohexane-1,2 diformate plasticizer and bis(2-ethylhexyl) terephthalate; the plasticizer can further comprise one or more of an epoxy compound, an aliphatic diester compound, a polyol benzoate compound, a citrate ester compound and a trimellitate ester compound. The prepared compound environment-friendly plasticizer can be used as a main plasticizer for resin such as polyvinyl chloride, has the advantages of good solubility, high plasticizing efficiency, heat resistance, cold resistance, pollution resistance, extraction resistance, good mobility, good electric insulativity, light and heat stability and the like; a preparation method is simple in process, low in process cost and wide in application range in plastic product processing industries and has high practical value.

Deng Wenting

Papers

Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN

Compound environment-friendly plasticizer for polyvinyl chloride resin and preparation method of plasticizer