Journal ArticleDOI
Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN
Reads0
Chats0
TLDR
In vivo assay indicated that Scutellarin possessed anti-cancer effect on xenograft without triggering toxic effect, suggesting that ScUTellarin might serve as a potential therapeutic agent in RCC treatment.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2018-09-05. It has received 39 citations till now. The article focuses on the topics: Scutellarin & PI3K/AKT/mTOR pathway.read more
Citations
More filters
Journal ArticleDOI
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Zhanjun Ma,Jingjing Yang,Yang Yang,Xue-Xi Wang,Guohu Chen,An-Cheng Shi,Yubao Lu,Shouning Jia,Xuewen Kang,Li Lu +9 more
TL;DR: It is suggested that RA exhibited anticancer effects in osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway, which might be a biological target for RA in ostea cells.
Journal ArticleDOI
Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways.
Fuen Liu,Lei Li,Wei Lu,Zhenfei Ding,Wei Huang,Ye Tian Li,Chao Cheng,Wen Shan Shan,Jiegou Xu,Wei He,Zhanghui,Zongsheng Yin +11 more
TL;DR: It is shown that scutellarin could inhibit inflammation and protects cartilage from degeneration in vitro and in vivo and indicates that scUTellarin may be a potential drug for the treatment of OA.
Journal ArticleDOI
Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways
TL;DR: A flavonoid isolated from Erigeron breviscapus (Vant.) Hand.
Journal ArticleDOI
Scutellarin inhibits the invasive potential of malignant melanoma cells through the suppression epithelial-mesenchymal transition and angiogenesis via the PI3K/Akt/mTOR signaling pathway.
TL;DR: Results indicated that scutellarin could markedly inhibit the invasive potential of melanoma cell lines by suppressing the EMT and angiogenesis through the PI3K/Akt/mTOR signaling pathway, which suggests that scUTellarin might be a potential compound in malignant melanoma treatment.
Journal ArticleDOI
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
TL;DR: Wang et al. as discussed by the authors demonstrated that Scutellarin may ameliorate colitis-associated colorectal cancer by weakening Wnt/β-catenin signaling cascade.
References
More filters
Journal ArticleDOI
Cancer statistics, 2013
TL;DR: Overall cancer death rates have declined 20% from their peak in 1991 to 2009 and can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket and other underserved populations.
Journal ArticleDOI
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
Journal ArticleDOI
The functions and regulation of the PTEN tumour suppressor
TL;DR: The repertoire of PTEN functions has recently been expanded to include phosphatase-independent activities and crucial functions within the nucleus, which will undoubtedly inform the rational design of novel therapies.
Journal ArticleDOI
Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity
Wen Hong Shen,Adayabalam S. Balajee,Jianli Wang,Hong Wu,Charis Eng,Pier Paolo Pandolfi,Yuxin Yin +6 more
TL;DR: It is proposed that PTEN acts as a guardian of genome integrity through the physical interaction with centromeres and control of DNA repair, and a nuclear function for PTEN in controlling chromosomal integrity is reported.
Journal ArticleDOI
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway.
Jiri Polivka,Filip Janku +1 more
TL;DR: Novel approaches to PI3K/AKT/mTOR pathway inhibition together with a better understanding of prognostic and predictive markers have the potential to significantly improve the future care of cancer patients in the current era of personalized cancer medicine.
Related Papers (5)
Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway
Haitao Xu,Songyan Zhang +1 more