Showing papers by "Denise M. Monack published in 1988"
Journal Article•
TL;DR: It is found that a single base-pair change is associated with the change between the virulent and avirulent phases and corresponds to a frameshift mutation in the vir locus.
Abstract: By a phenomenon known as phase-variation Bordetella pertussis is capable of changing between a virulent-phase in which multiple virulence-associated determinants are expressed, and an avirulent-phase in which the virulence-associated determinants are not expressed. Mutations in the vir locus of B. pertussis have a similar effect. We have examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation. We have found that a single base-pair change is associated with the change between the virulent and avirulent phases. This single base-pair change corresponds to a frameshift mutation in the vir locus.
8 citations
Journal Article•
TL;DR: In this article, the authors examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation and found that a single base-pair change is associated with the change between the virulent and avirulent phases.
Abstract: By a phenomenon known as phase-variation Bordetella pertussis is capable of changing between a virulent-phase in which multiple virulence-associated determinants are expressed, and an avirulent-phase in which the virulence-associated determinants are not expressed. Mutations in the vir locus of B. pertussis have a similar effect. We have examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation. We have found that a single base-pair change is associated with the change between the virulent and avirulent phases. This single base-pair change corresponds to a frameshift mutation in the vir locus.
5 citations