Denise Visser

TL;DR: In MCI/AD patients, [18F]flortaucipir binding in entorhinal, limbic, and neocortical regions was associated with cortical atrophy, and in controls, there were no significant associations.

TL;DR: In this paper , the authors examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A + ) and tau PETpositive (T + ) in the medial temporal lobe and/or in the temporal neocortex, and compared them with A + T − and A − T − groups.

TL;DR: In this article, the authors used linear regressions to investigate associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognition and atrophy.

TL;DR: Tau pathology and low rCBF were both independently associated with worse cognitive performance and indicate that each biomarker may independently contribute to cognitive impairment in Alzheimer’s disease.

TL;DR: While TRT repeatability was good for all models used, quantitative methods performed slightly better than semi-quantitative methods.