Dennis Murphy

TL;DR: Several novel anti-TB targets have been proposed as potential opportunities to improve present therapeutic treatments for this disease and the advantages and liabilities of each target are discussed in the context of enzymology, bacterial pathways, target tractability, and drug development.

TL;DR: Co-opting particular isoforms from large, diverse protein families seems to be a common theme in the evolution of miRNA biogenesis, and the occurrence of multiple homologues to RNA-binding and Argonaute/PIWI proteins also suggests the possible existence of further pathways for additional types of ncRNAs.

TL;DR: Sulfonylfuran urea 1 was identified in a high-throughput screening campaign as a potent and non-selective EL inhibitor, and modifications leading to improved LPL selectivity were identified.

TL;DR: This novel method for measuring pleural pressure chronically in conscious rats will facilitate evaluation of the effects of drugs, environmental agents, or disease on respiratory function by allowing repeated and simultaneous measurements of both ventilatory (breathing) patterns and lung function in conscious animals.

TL;DR: Progress has been made in characterizing the genetic program of MTB, activated by DosR (DevR) signal transduction that allows adaptation to the hypoxic, nutrient limiting granuloma microenvironment, and recent work, especially the identification genes involved in regulatory networks and the Enduring Hypoxic Response, hold promise for developing new drugs targeting dormancy phase MTB.