Synthesis and biological activity of pyrrole, pyrroline and pyrrolidine derivatives with two aryl groups on adjacent positions

A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.

A palladium catalyzed C−H bond functionalization system that operates under ambient and aerobic conditions can be used to alkenylate pyrroles with control of regioselectivty. A steric and electronic control strategy can be used to influence positional control in the C−H bond functionalization process that results in either the C2 or C3 alkenylated products. Air, molecular oxygen, or tBuOOBz can be used as reoxidant in this mild process, and the reaction works on a range of substrates. Finally a catalytic aerobic annulation strategy is described that can be controlled to produce cyclization at either the C2 or C3 positions, thus forming diverse pyrrole products.

Mild aerobic oxidative palladium (II) catalyzed C-H bond functionalization: regioselective and switchable C-H alkenylation and annulation of pyrroles.

Synthesis of Polyquinane Natural Products: An Update.

Fluorinated phosphonates: synthesis and biomedical application.

A most useful strategy has been devised for the synthesis of 3-substituted pyrroles on the basis of the kinetic electrophilic substitution of 1-(triisopropylsilyl) pyrrole (1) at the β position and subsequent fluoride ion induced desilylation. This now becomes the preferred route to 3-monosubstituted pyrroles

N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

Protecting groups for the pyrrole and indole nitrogen atom. The [2-(trimethylsilyl)ethoxy]methyl moiety. Lithiation of 1-[[2-(trimethylsilyl)ethoxy]methyl]pyrrole

An Efficient Synthesis of N-α-Fmoc-4-(Phosphonodifluoromethyl)-l- phenylalanine

Total synthesis of .beta.-santalol

Total synthesis of (-)-.alpha.-acoradiene and (-)-.alpha.-cedrene

Dennis Solas

Papers

N-(Triisopropylsilyl)pyrrole. A progenitor "par excellence" of 3-substituted pyrroles

Protecting groups for the pyrrole and indole nitrogen atom. The [2-(trimethylsilyl)ethoxy]methyl moiety. Lithiation of 1-[[2-(trimethylsilyl)ethoxy]methyl]pyrrole

An Efficient Synthesis of N-α-Fmoc-4-(Phosphonodifluoromethyl)-l- phenylalanine

Total synthesis of .beta.-santalol

Total synthesis of (-)-.alpha.-acoradiene and (-)-.alpha.-cedrene