Derin Cobia

TL;DR: The feasibility of using a simple algorithm for clinicoanatomical classification in PPA is demonstrated using a 2-dimensional template that reflects performance on tests of syntax and lexical semantics and whether this subtyping can improve clinical prediction of the underlying neuropathologic condition is investigated.

TL;DR: The results suggest that the unique features, which sharply differentiate the PPA variants at the early to middle stages, may lose their distinctiveness as the degeneration becomes more severe.

TL;DR: Results show that PPA reflects a selective disruption of the language network as a whole, with no rigid boundaries between subtypes, and reveal anatomical correlates of language that could not have been surmised in patients with aphasia resulting from cerebrovascular lesions.

TL;DR: The left sided asymmetry and perisylvian extension of the atrophy explains the more profound impairment of word than object usage and provides the anatomical basis for distinguishing the semantic variant of primary progressive aphasia from the partially overlapping group of patients that fulfil the widely accepted diagnostic criteria for semantic dementia.

TL;DR: In this article, the authors provide quantitative measures of changes in cortical atrophy over a 2-year period associated with three subtypes of primary progressive aphasia (PPA) using whole-brain vertex-wise and region-of-interest (ROI) neuroimaging methods.