D
Deuan C. Jones
Researcher at University of Dundee
Publications - 18
Citations - 768
Deuan C. Jones is an academic researcher from University of Dundee. The author has contributed to research in topics: Trypanosoma brucei & Glycoprotein. The author has an hindex of 15, co-authored 18 publications receiving 716 citations. Previous affiliations of Deuan C. Jones include University of Alberta.
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Journal ArticleDOI
Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography
Stephen Patterson,Magnus S. Alphey,Deuan C. Jones,Emma Shanks,Ian P. Street,Julie A. Frearson,Paul G. Wyatt,Ian H. Gilbert,Alan H. Fairlamb +8 more
TL;DR: The discovery, synthesis, and development of a novel series of TryR inhibitors based on a 3,4-dihydroquinazoline scaffold are reported, representing the first report of a high resolution complex between a noncovalent ligand and this enzyme.
Journal ArticleDOI
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
Deuan C. Jones,Irene Hallyburton,Laste Stojanovski,Kevin D. Read,Julie A. Frearson,Alan H. Fairlamb +5 more
TL;DR: Phenotypic screening of the LOPAC library identified several potent and selective inhibitors of African trypanosomes and the κ-opioid agonist (+)-U50,488 represents a novel lead for drug discovery against sleeping sickness.
Journal ArticleDOI
Deletion of the glucosidase II gene in Trypanosoma brucei reveals novel N-glycosylation mechanisms in the biosynthesis of variant surface glycoprotein.
TL;DR: The creation of a bloodstream-form T. brucei mutant that is deficient in the endoplasmic reticulum enzyme glucosidase II is described and points to fundamental differences in the specificities of host and parasite glycosyltransferases that initiate the synthesis of complex N-glycans.
Journal ArticleDOI
Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis
John L. Richardson,Isabelle R. E. Nett,Deuan C. Jones,Mohamed H. Abdille,Ian H. Gilbert,Alan H. Fairlamb +5 more
TL;DR: The LOPAC1280 library of 1266 compounds was screened against TryR and the top hits evaluated against glutathione reductase and T. brucei parasites included a number of known tricyclic neuroleptic drugs along with other new scaffolds for TryR.
Journal ArticleDOI
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei
Daniel Spinks,Emma Shanks,Laura A. T. Cleghorn,Stuart P. McElroy,Deuan C. Jones,Daniel James,Alan H. Fairlamb,Julie A. Frearson,Paul G. Wyatt,Ian H. Gilbert +9 more
TL;DR: The screening of a 62 000 compound library against T. brucei TryR yielded low micromolar inhibitors of the enzyme and growth of the parasite.