D
Devadasan Velmurugan
Researcher at University of Madras
Publications - 550
Citations - 3409
Devadasan Velmurugan is an academic researcher from University of Madras. The author has contributed to research in topics: Ring (chemistry) & Dihedral angle. The author has an hindex of 24, co-authored 544 publications receiving 2893 citations. Previous affiliations of Devadasan Velmurugan include SRM University & Bharathiar University.
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Identification of novel Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitors using computational approaches.
TL;DR: Two leads are identified which have better binding free energy compared to known inhibitors and showed stable hydrogen bonding and hydrophobic contacts with β barrel cavity lining residues in the active site of the dimer interface and can be considered as novel cores for future development of drugs to inhibit NAMPT function.
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Crystal structure of 6-(4-chlorophenyl)-6a-nitro-6,6a,6b,7,9,11a-hexahydrospiro[chromeno[3′,4′:3,4]pyrrolo[1,2-c]thiazole-11,11′-indeno[1,2-b]quinoxaline] chloroform monosolvate
Nithya Sivakumar,Vijayan Viswanathan,Jonnalagadda Naga Siva Rao,Raghavachary Raghunathan,Devadasan Velmurugan +4 more
TL;DR: In the title compound, C33H23ClN4O3S·CHCl3, the thiazole ring adopts an envelope conformation with the N atom as the flap, and the pyrrolidine ring adopTS a half-chair conformation.
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Crystal structures of N -(4-chloro-phen-yl)-2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]acetamide and N -(3-chloro-phen-yl)-2-[(4,6-di-amino-pyrimidin-2-yl)sulfan-yl]acetamide.
S. Subasri,Timiri Ajay Kumar,Barij Nayan Sinha,Venkatesan Jayaprakash,Vijayan Viswanathan,Devadasan Velmurugan +5 more
TL;DR: The title compounds, (I) and (II), are 2-[(diaminopyrimidin-2-yl)sulfanyl]acetamides, which have a folded conformation and the pyrimidine ring is inclined to the benzene ring.
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2-Methyl-4-(naphthalen-2-yl)-3a-nitro-3,3a,4,9b-tetra-hydro-2H-spiro-[chromeno[3,4-c]pyrrole-1,3'-indolin]-2'-one.
Seenivasan Karthiga Devi,Thothadri Srinivasan,Jonnalagadda Naga Siva Rao,Raghavachary Raghunathan,Devadasan Velmurugan +4 more
TL;DR: In the title compound, C29H23N3O4, the 2-methylpyrrolidine ring adopts a twist conformation on the N—C bond involving the spiro C atom, while the hydropyran ring adopTS an envelope conformation with the methine C atom bonded to the O atom as the flap.
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1,2,3,4,5,6,7,8,9,10-Decahydro-3,3,6,6-tetramethyl-1,8-dioxo-10-vinylacridin-9-ylmethyl Acetate
TL;DR: In this paper, the piperidine ring adopts a sofa conformation, while that of the outer rings is half-chair, and the packing is stabilized by C-H⋯O hydrogen bonds.