Devin V. McAllister

TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.

TL;DR: Microfabrication techniques for silicon, metal, and biodegradable polymer microneedle arrays having solid and hollow bores with tapered and beveled tips and feature sizes from 1 to 1,000 μm allowed flow of microliter quantities into skin in vivo, including microinjection of insulin to reduce blood glucose levels in diabetic rats.

TL;DR: Microneedles have been developed to reduce needle insertion pain and tissue trauma and to provide controlled delivery across the skin, and these needles have been shown to be robust enough to penetrate skin and dramatically increase skin permeability to macromolecules.

TL;DR: Safety, immunogenicity, and acceptability of the first-in-man study on single, dissolvable microneedle patch vaccination against influenza are described and secondary safety outcomes are new-onset chronic illnesses within 180 days and unsolicited adverse events within 28 days, all analysed by intention to treat.

TL;DR: These microneedles were fabricated using the Black Silicon Method, which is a reactive ion etching process in which an SF/sub 6//O/sub 2/ plasma etches silicon anisotropically and demonstrated excellent mechanical properties and skin permeability to calcein, a model drug, by up to four orders of magnitude.