D
Di-Hwei Hsu
Publications - 4
Citations - 1651
Di-Hwei Hsu is an academic researcher. The author has contributed to research in topics: Antigen & Exosome. The author has an hindex of 3, co-authored 4 publications receiving 1413 citations.
Papers
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Journal ArticleDOI
A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
Michael A. Morse,Jennifer Garst,Takuya Osada,Shubi Khan,Amy Hobeika,Timothy M. Clay,Nancy Valente,Revati Shreeniwas,Mary Sutton,Alain Delcayre,Di-Hwei Hsu,Jean-Bernard Le Pecq,H. Kim Lyerly +12 more
TL;DR: Production of the DEX vaccine was feasible and DEX therapy was well tolerated in patients with advanced NSCLC, and some patients experienced long term stability of disease and activation of immune effectors.
Journal ArticleDOI
Production and characterization of clinical grade exosomes derived from dendritic cells.
Henry Lamparski,Anita Metha-Damani,Jenq-Yuan Yao,Sanjay Patel,Di-Hwei Hsu,Curtis L. Ruegg,Jean-Bernard Le Pecq +6 more
TL;DR: The combination of a rapid and reproducible purification method and quality control assays for exosomes has allowed for its evaluation as a cancer vaccine in clinical trials and the following quality control Assays to standardize the exosome vaccine are developed.
Patent
Methods of producing membrane vesicles
TL;DR: In this paper, the authors present methods of preparing membrane vesicles (in particular exosomes) released by various types of mammalian cells, comprising diafiltration and/or density cushion centrifugation.
Patent
Functionalization of t cell derived vesicles and use thereof for the preparation of immunogenic pharmaceutical compositions
Yafei Latham Street Hou,Di-Hwei Hsu,Henry Lamparski,Jean-Bernard Le Pecq,Anita Mehta-Damani,Pedro Paz +5 more
TL;DR: In this paper, compositions comprising vesicles released' from activated T lymphocytes, as well as methods for their production and uses, are discussed, and methods of delivering molecules selectively or specifically to target cells using said vesicle.