Alain Delcayre

TL;DR: Production of the DEX vaccine was feasible and DEX therapy was well tolerated in patients with advanced NSCLC, and some patients experienced long term stability of disease and activation of immune effectors.

TL;DR: It is shown that an integrin-binding protein initially described in milk-fat globule, MFG-E8 (also known as lactadherin), is expressed in and around blood vessels and has a crucial role in VEGF-dependent neovascularization in the adult mouse.

TL;DR: The mode of secretion can determine the immunogenicity of tumor antigens and that manipulation of the mode of antigen secretion may be used to optimize antitumor vaccination protocols.

TL;DR: It is demonstrated that the mode of secretion and trafficking can influence the immunogenicity of different human TAAs, and may explain the lack of immunogenicicity of non-mutated TAAs found in cancer patients, and suggested that exosomal targeting could enhance future anti-tumor vaccination protocols.

TL;DR: The Exosome Display technology is very versatile since soluble, membrane-bound, trans-membrane or multimeric antigens that are not naturally found on exosomes can now be efficiently expressed at their surface in a native conformation.