D
Di Liu
Researcher at Washington University in St. Louis
Publications - 22
Citations - 1351
Di Liu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Metabolic engineering & Metabolic pathway. The author has an hindex of 15, co-authored 21 publications receiving 1026 citations. Previous affiliations of Di Liu include Sandia National Laboratories & University of Washington.
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Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis.
TL;DR: In vivo population quality control (PopQC) is developed to continuously select for high-performing, nongenetic variants of biosynthetic pathways and it is confirmed that PopQC improves ensemble biosynthesis by selecting for nonganetic high performers.
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Applications and advances of metabolite biosensors for metabolic engineering
TL;DR: This work reviews recent developments in biosensors in each of these mechanistic classes, with considerations towards how these sensors are engineered, how new sensing mechanisms have led to improved function, and the advantages and disadvantages of each ofThese sensing mechanisms in relevant applications.
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Negative feedback regulation of fatty acid production based on a malonyl-CoA sensor-actuator.
TL;DR: It is shown that the regulatory circuit effectively alleviates the toxicity associated with acetyl-CoA carboxylase overexpression and increases fatty acid titer and productivity by 34% and 33%, respectively when used to regulate the fatty acid pathway.
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Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors
TL;DR: This work sheds light on fundamental limits of synthetic biology designs and provides quantitative guidelines for biosensor design in applications such as dynamic pathway control, strain optimization, and real-time monitoring of metabolism.
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Engineered Crumpled Graphene Oxide Nanocomposite Membrane Assemblies for Advanced Water Treatment Processes
Yi Jiang,Wei-Ning Wang,Wei-Ning Wang,Di Liu,Yao Nie,Wenlu Li,Jiewei Wu,Fuzhong Zhang,Pratim Biswas,John D. Fortner +9 more
TL;DR: This is the first demonstration of 3D, crumpled graphene oxide based nanocomposite structures applied specifically as (re)active membrane assemblies and highlights the material's platform potential for a truly tailored approach for next generation water treatment and separation technologies.