D
Didier Clarençon
Researcher at French Institute of Health and Medical Research
Publications - 15
Citations - 1292
Didier Clarençon is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Vagus nerve stimulation & Vagal tone. The author has an hindex of 11, co-authored 15 publications receiving 1107 citations. Previous affiliations of Didier Clarençon include Joseph Fourier University & University of Grenoble.
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Journal ArticleDOI
Chronic vagus nerve stimulation in Crohn's disease: a 6‐month follow‐up pilot study
Bruno Bonaz,Valérie Sinniger,Dominique Hoffmann,Didier Clarençon,Nicolas Mathieu,Cécile Dantzer,Laurent Vercueil,Chloé Picq,Candice Trocme,Patrice Faure,Jean-Luc Cracowski,Sonia Pellissier +11 more
TL;DR: The results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD with a restored vagal tone.
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Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green.
André Peinnequin,Catherine Mouret,Olivier Birot,Antonia Alonso,Jacques Mathieu,Didier Clarençon,Diane Agay,Yves Chancerelle,Eric Multon +8 more
TL;DR: SYBR Green real-time RT-PCR protocols to assay pro-inflammatory cytokines, cytokine receptors and related molecules and related molecule mRNA in rats and enables normalisation against several housekeeping genes dependent on the specific experimental treatments and tissues.
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Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway.
TL;DR: Both vagal afferents and efferents are activated by VNS, which is used as an anti‐TNF therapy in inflammatory diseases were TNF is a key cytokine as represented by experimental sepsis, postoperative ileus, burn‐induced intestinal barrier injury, colitis.
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Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease.
Julien Meregnani,Didier Clarençon,Mylene Vivier,André Peinnequin,Catherine Mouret,Valérie Sinniger,Chloé Picq,Agnès Job,Frédéric Canini,Muriel R. Jacquier-Sarlin,Bruno Bonaz +10 more
TL;DR: The data argue for an anti-inflammatory role of vagus nerve stimulation chronically performed in freely moving rats with colitis and provide potential therapeutic applications for patients with inflammatory bowel diseases.
Journal ArticleDOI
Dynamic Causal Modelling and physiological confounds: A functional MRI study of vagus nerve stimulation
Sebastien Reyt,Chloé Picq,Chloé Picq,Valérie Sinniger,Didier Clarençon,Bruno Bonaz,Olivier David,Olivier David +7 more
TL;DR: The study indicates that current developments of DCM are robust to psychophysiological responses to some extent, but does not exclude the need to develop specific models of brain - body interactions within the DCM framework to better estimate neuronal connectivity from fMRI time series.