D
Didier Dubreuil
Researcher at Centre national de la recherche scientifique
Publications - 45
Citations - 331
Didier Dubreuil is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Inositol & Reactivity (chemistry). The author has an hindex of 11, co-authored 45 publications receiving 314 citations. Previous affiliations of Didier Dubreuil include Bayer HealthCare Pharmaceuticals & University of Nantes.
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Journal ArticleDOI
Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2(+)-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinase.
Stephen T. Safrany,Richard J.H. Wojcikiewicz,J. Strupish,Stefan R. Nahorski,Didier Dubreuil,Jeannine Cleophax,Stephane D. Gero,Barry V. L. Potter +7 more
TL;DR: 6‐Deoxy‐Ins(1,4,5)P3 was a full agonist, but was some 70‐fold less potent than Ins (1, 4,5]P3 (EC30 = 0.09 μM), indicating that the 6‐hydroxyl group of Ins(2,3,3)P2 is most important for receptor binding and stimulation of Ca2+ release, but is not an essential structural feature.
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Ring Contraction Methodology for the Synthesis of Pyrroles
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Preparation of functionalized aryl- and heteroarylpyridazines by nickel-catalyzed electrochemical cross-coupling reactions.
Stéphane Sengmany,Eric Léonel,Frantz Polissaint,Jean-Yves Nédélec,Muriel Pipelier,Christine Thobie-Gautier,Didier Dubreuil +6 more
TL;DR: A general efficient electrochemical method for the preparation of aryl- and heteroarylpyridazines in a nickel-catalyzed cross-coupling reaction of 3-chloro-6-methoxypyridazine and 3- chloro- 6-methylpyridine with a range of functionalized aryL or heteroaryl halides is reported.
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Synthesis and reactivity of N-selenoacylamidines precursors of selenoheterocycles
TL;DR: In this article, a new synthesis and reactivity of stable selenaazadienes are discussed, and an interpretation of the reactivities of these systems, experimentaly compared to their thia analogues, is based on their physico-chemical parameters and correlated to the theoretical calculations of their frontier molecular orbital energy levels.
Journal ArticleDOI
Stereoselective synthesis of 6-deoxy and 3,6-dideoxy-D-myo-inositol precursors of deoxy-myo-inositol phosphate analogues from D-galactose
Didier Dubreuil,Jeannine Cleophax,Mauro V. de Almeida,Catherine Verre-Sebrie,Jérôme Liaigre,George Vass,Stephane D. Gero +6 more
TL;DR: The synthesis of chiral protected 6-deoxy-myo-inositol derivatives from D-galactose is described in this article, where Ferrier rearrangement of hexenogalactopyranosides has been employed to produce the corresponding 6 deoxy-cyclohexanone polyols.