Current Organic Chemistry 

About: Current Organic Chemistry is an academic journal published by Bentham Science Publishers. The journal publishes majorly in the area(s): Catalysis & Chemistry. It has an ISSN identifier of 1385-2728. Over the lifetime, 2897 publications have been published receiving 69402 citations.

Recent Progress in the Synthesis of Quinolines

Abstract: New developments in the chemistry of quinoline derivatives are reviewed. Two general synthetic routes based on the utilization of mono-substituted or ortho-substituted anilines are discussed. Their major methods and modifications are analyzed. syntheses. These classical syntheses are well-known and still frequently used for the preparation of pharmaceutical agents, ligands and functional materials bearing a quinoline backbone. However, current methods for quinoline synthesis often do not allow for adequate diversity and substitution on the quinoline ring system (19). Recent developments in the chemistry of quinoline derivatives have demonstrated that new metal-catalyzed coupling cyclizations or acid catalyzed cycloaddition of appropriate precursors could compete with classical syntheses in the efficacy and rapidity of the quinoline construction. These new developments have prompted us to review and analyze their major methods and modifications.

The Potential of African Plants as a Source of Drugs

Abstract: African plants have long been the source of important products with nutritional and therapeutical value. Coffee originates from Ethiopia, Strophanthus species are strong arrow poisons and supply cardenolides for use against cardiac insufficiency, the Catharanthus roseus alkaloids are well-known antileukaemic agents - just to mention a few examples. Research is continuing on the vegetable material from this continent in an endeavour to find new compounds of therapeutic interest. An outline is presented here covering the results obtained by the Institute of Pharmacognosy and Phytochemistry of the University of Lausanne during 15 years' work on African plants. The strategy employed for the study of these plants is outlined, covering all aspects from the selection of plant material to the isolation of pure natural products. Different bioactivities have been investigated: the search for new antifungal, molluscicidal and larvicidal agents has been the most important axis. Results are also included for antibacterial, cytotoxicity, anti-inflammatory testing

Advances in Bioconjugation.

Abstract: Bioconjugation is a burgeoning field of research. Novel methods for the mild and site-specific derivatization of proteins, DNA, RNA, and carbohydrates have been developed for applications such as ligand discovery, disease diagnosis, and high-throughput screening. These powerful methods owe their existence to the discovery of chemoselective reactions that enable bioconjugation under physiological conditions—a tremendous achievement of modern organic chemistry. Here, we review recent advances in bioconjugation chemistry. Additionally, we discuss the stability of bioconjugation linkages—an important but often overlooked aspect of the field. We anticipate that this information will help investigators choose optimal linkages for their applications. Moreover, we hope that the noted limitations of existing bioconjugation methods will provide inspiration to modern organic chemists.

Organocatalytic domino reactions

Abstract: Since the rediscovery of proline in 2000 as catalyst in aldol reaction by List, Barbas and Lerner and, soon after, the development of iminium catalysis by D. W. C. MacMillan, the emergence of organocatalysis as an important tool in organic synthesis is outstanding. During the last years, several research groups have worked in the development of new and powerful methodologies that allow us to build difficult molecules with high yields and enantioselectivities in a metal-free environment. Moreover, the possibility to join two or more organocatalytic reactions in one process has become one challenging goal for chemists, probably due to the costly protecting groups and time-consuming purification procedures after each synthetic step that are one of the common issues in organic synthesis. To circumvent these problems, tandem, domino, cascade or multicomponent organocatalytic reactions have been utilized for the efficient diastereo- and enantioselective construction of complex molecules from simple precursors in simple processes. For example, different tandem organocatalytic reactions such as cyclopropanation, aziridination, Michael-aldol, Michael-?-alkylation, etc. have been developed since 2006 with excellent yields and stereoselectivities. Herein, we describe the last trends and examples of organocatalytic domino reactions. This review aims to cover and discuss the current development of this fast growing field.