D
Dietrich Hoffmann
Researcher at National Institutes of Health
Publications - 311
Citations - 18484
Dietrich Hoffmann is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Sidestream smoke & Tobacco smoke. The author has an hindex of 68, co-authored 311 publications receiving 18027 citations. Previous affiliations of Dietrich Hoffmann include York University & Kettering University.
Papers
More filters
Journal ArticleDOI
The changing cigarette, 1950-1995
Dietrich Hoffmann,Ilse Hoffmann +1 more
TL;DR: From a public health perspective, nicotine in the smoke needs to be lowered to a level at which there is no induction of dependence on tobacco, and further needs for reducing the toxicity and carcinogenicity of cigarette smoke are discussed.
Journal ArticleDOI
The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder.
TL;DR: The anticipated reduction of mortality rates from chronic diseases among cigarette smokers did not occur, primarily, because of a major adjustment in smoking intensity and depth of inhalation by the habitual smokers.
Journal ArticleDOI
Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
TL;DR: Several lines of evidence strongly indicate that tobacco-specific nitrosamines have a major role, especially in the causation of oral cancer in snuff-dippers, and should be ideal markers for assessing human exposure to, and metabolic activation of, tobacco smoke carcinogens.
Journal ArticleDOI
The changing cigarette
TL;DR: The product changes, the smokers' dependence on nicotine which governs their smoking patterns, and the modified smoke chemistry support the hypothesis that differences in PAH and TSNA exposure may be linked to the observed different incidences of squamous cell cancer and adenocarcinoma of the lung.
Journal ArticleDOI
Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines : chemistry, biochemistry, carcinogenicity, and relevance to humans
TL;DR: Evidence is presented that strongly supports the concept that TSNA contribute to the increased risk for cancer of the upper digestive tract in tobacco chewers and for the increase risk of lung cancer, especially pulmonary adenocarcinoma, in smokers.