D
Dietrich Hoffmann
Researcher at National Institutes of Health
Publications - 311
Citations - 18484
Dietrich Hoffmann is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Sidestream smoke & Tobacco smoke. The author has an hindex of 68, co-authored 311 publications receiving 18027 citations. Previous affiliations of Dietrich Hoffmann include York University & Kettering University.
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Journal ArticleDOI
Synthesis of Angular Ring Methoxy-5-methylchrysenes and 5-Methylchrysenols
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The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols.
Neil Trushin,Gerhard Leder,Karam El-Bayoumy,Dietrich Hoffmann,Hans G. Beger,Doris Henne-Bruns,Marco Ramadani,Bogdan Prokopczyk +7 more
TL;DR: In human pancreatic tissues, there is intraindividual variability regarding the capacity for, and stereoselectivity of, carbonyl reduction of NNK.
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Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells.
N. Matsukura,James C. Willey,Masao Miyashita,B. Taffe,Dietrich Hoffmann,C. Waldren,Theodore T. Puck,Curtis C. Harris +7 more
TL;DR: Results indicate that CSC and fractions of CSC can directly produce a spectrum of mutations, through both deletional and non-dysjunctional mechanisms of a kind known to lead to inactivation of tumor suppressor genes.
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