Institution
Dana Corporation
Company•Maumee, Ohio, United States•
About: Dana Corporation is a company organization based out in Maumee, Ohio, United States. It is known for research contribution in the topics: Axle & Clutch. The organization has 6171 authors who have published 6748 publications receiving 177866 citations.
Topics: Axle, Clutch, Cancer, Population, Gasket
Papers published on a yearly basis
Papers
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TL;DR: Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.
Abstract: Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that links tissue and organ systems. The emerging tools of network medicine offer a platform to explore systematically not only the molecular complexity of a particular disease, leading to the identification of disease modules and pathways, but also the molecular relationships among apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.
3,978 citations
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TL;DR: Data from the Framingham Heart Study indicate that the incidence of congestive heart failure increases with age and is higher in men than in women, and diabetes mellitus and electrocardiographic left ventricular hypertrophy are also associated with an increased risk of heart failure.
2,249 citations
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TL;DR: Advances in the treatment of hypertension, myocardial ischemia, and valvular heart disease during the four decades of observation did not translate into appreciable improvements in overall survival after the onset of CHF in this large, unselected population.
Abstract: BACKGROUND Relatively limited epidemiological data are available regarding the prognosis of congestive heart failure (CHF) and temporal changes in survival after its onset in a population-based setting. METHODS AND RESULTS Proportional hazards models were used to evaluate the effects of selected clinical variables on survival after the onset of CHF among 652 members of the Framingham Heart Study (51% men; mean age, 70.0 +/- 10.8 years) who developed CHF between 1948 and 1988. Subjects were older at the diagnosis of heart failure in the later decades of this study (mean age at heart failure diagnosis, 57.3 +/- 7.6 years in the 1950s, 65.9 +/- 7.9 years in the 1960s, 71.6 +/- 9.4 years in the 1970s, and 76.4 +/- 10.0 years in the 1980s; p < 0.001). Median survival after the onset of heart failure was 1.7 years in men and 3.2 years in women. Overall, 1-year and 5-year survival rates were 57% and 25% in men and 64% and 38% in women, respectively. Survival was better in women than in men (age-adjusted hazards ratio for mortality, 0.64; 95% CI, 0.54-0.77). Mortality increased with advancing age in both sexes (hazards ratio for men, 1.27 per decade of age; 95% CI, 1.09-1.47; hazards ratio for women, 1.61 per decade of age; 95% CI, 1.37-1.90). Adjusting for age, there was no significant temporal change in the prognosis of CHF during the 40 years of observation (hazards ratio for men for mortality, 1.08 per calendar decade; 95% CI, 0.92-1.27; hazards ratio for women for mortality, 1.02 per calendar decade; 95% CI, 0.83-1.26). CONCLUSIONS CHF remains highly lethal, with better prognosis in women and in younger individuals. Advances in the treatment of hypertension, myocardial ischemia, and valvular heart disease during the four decades of observation did not translate into appreciable improvements in overall survival after the onset of CHF in this large, unselected population.
1,836 citations
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Wellcome Trust1, University of London2, Dana Corporation3, University of Toronto4, Federal University of São Paulo5, Duke University6, University of Wisconsin-Madison7, University of Oxford8, John E. Fogarty International Center9, University of Queensland10, Chinese Center for Disease Control and Prevention11, Harvard University12, Johns Hopkins University13, Muhimbili University of Health and Allied Sciences14, King's College London15, University of Ibadan16, Cayetano Heredia University17, University of California, Berkeley18, Indian Institute of Science19, University of Cambridge20, World Health Organization21, Health Canada22, University of Cape Town23, National Health and Medical Research Council24, Medical Research Council25, Canadian Institutes of Health Research26, National Institutes of Health27
TL;DR: A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action and investment.
Abstract: A consortium of researchers, advocates and clinicians announces here research priorities for improving the lives of people with mental illness around the world, and calls for urgent action and investment.
1,726 citations
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TL;DR: A new PBC theory is developed which extends to a broader class of systems the aforementioned energy-balancing stabilization mechanism and the structure invariance and considers instead port-controlled Hamiltonian models, which result from the network modelling of energy-conserving lumped-parameter physical systems with independent storage elements, and strictly contain the class of EL models.
1,444 citations
Authors
Showing all 6174 results
Name | H-index | Papers | Citations |
---|---|---|---|
Daniel Levy | 212 | 933 | 194778 |
Matthew Meyerson | 194 | 553 | 243726 |
William B. Kannel | 188 | 533 | 175659 |
Stuart H. Orkin | 186 | 715 | 112182 |
Paul G. Richardson | 183 | 1533 | 155912 |
Bruce M. Spiegelman | 179 | 434 | 158009 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
David R. Williams | 178 | 2034 | 138789 |
David L. Kaplan | 177 | 1944 | 146082 |
Timothy A. Springer | 167 | 669 | 122421 |
Gordon J. Freeman | 164 | 579 | 105193 |
Todd R. Golub | 164 | 422 | 201457 |
Charles N. Serhan | 158 | 728 | 84810 |
Albert-László Barabási | 152 | 438 | 200119 |
Charles S. Fuchs | 148 | 886 | 80802 |