D
Dimas Tadeu Covas
Researcher at University of São Paulo
Publications - 418
Citations - 9228
Dimas Tadeu Covas is an academic researcher from University of São Paulo. The author has contributed to research in topics: Mesenchymal stem cell & Population. The author has an hindex of 37, co-authored 379 publications receiving 7630 citations. Previous affiliations of Dimas Tadeu Covas include Laboratory of Molecular Biology & Gulf Coast Regional Blood Center.
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Journal ArticleDOI
Mechanisms involved in the therapeutic properties of mesenchymal stem cells
Lindolfo da Silva Meirelles,Aparecida Maria Fontes,Dimas Tadeu Covas,Dimas Tadeu Covas,Arnold I. Caplan +4 more
TL;DR: Some of the molecules involved in the paracrine effects of MSCs are identified with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and how this knowledge could be advantageously used in clinical applications is discussed.
Journal ArticleDOI
Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts
Dimas Tadeu Covas,Rodrigo Alexandre Panepucci,Aparecida Maria Fontes,Wilson A. Silva,Maristela Delgado Orellana,Marcela Cristina Corrêa de Freitas,Luciano Neder,Anemari Ramos Dinarte dos Santos,Luiz César Peres,Maria Célia Jamur,Marco Antônio Zago +10 more
TL;DR: The results indicate that human MSC and pericytes are similar cells located in the wall of the vasculature, where they function as cell sources for repair and tissue maintenance, whereas fibroblasts are more differentiated cells with more restricted differentiation potential.
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Comparison of gene expression of umbilical cord vein and bone marrow-derived mesenchymal stem cells.
Rodrigo Alexandre Panepucci,J. L. C. Siufi,Wilson A. Silva,Rodrigo Proto‐Siquiera,Luciano Neder,Maristela Delgado Orellana,Vanderson Rocha,Dimas Tadeu Covas,Marco Antônio Zago +8 more
TL;DR: MSCs isolated from UC veins are functionally similar to BM‐MSCs, but differentially expressed genes may reflect differences related to their sites of origin: BM‐ MSCs would be more committed to osteogenesis, whereas UC‐MSC would beMore committed to angiogenesis.
Journal ArticleDOI
The Profile of Gene Expression of Human Marrow Mesenchymal Stem Cells
Wilson A. Silva,Dimas Tadeu Covas,Rodrigo Alexandre Panepucci,Rodrigo Proto-Siqueira,J. L. C. Siufi,Dalila Luciola Zanette,Anemari Ramos Dinarte dos Santos,Marco Antônio Zago +7 more
TL;DR: The profile of gene expression in MSCs is reported and the important contribution of extracellular protein products, adhesion molecules, cell motility, TGF‐β signaling, growth factor receptors, DNA repair, protein folding, and ubiquination are identified as part of their transcriptome.
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Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies.
N. C. Nadia de Cassia Noronha,Amanda Mizukami,Carolina Caliari-Oliveira,Juçara Gastaldi Cominal,Jose Lucas M. Rocha,Dimas Tadeu Covas,Kamilla Swiech,Kelen C. R. Malmegrim +7 more
TL;DR: Current priming approaches that aim to increase MSC therapeutic efficacy, including priming with cytokines and growth factors, hypoxia, pharmacological drugs, biomaterials, and different culture conditions, as well as other diverse molecules, are revised from current and future perspectives.