Mechanisms involved in the therapeutic properties of mesenchymal stem cells
Lindolfo da Silva Meirelles,Aparecida Maria Fontes,Dimas Tadeu Covas,Dimas Tadeu Covas,Arnold I. Caplan +4 more
TLDR
Some of the molecules involved in the paracrine effects of MSCs are identified with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and how this knowledge could be advantageously used in clinical applications is discussed.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2009-10-01 and is currently open access. It has received 1254 citations till now. The article focuses on the topics: Mesenchymal stem cell & Homing (hematopoietic).read more
Citations
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The MSC: An Injury Drugstore
Arnold I. Caplan,Diego Correa +1 more
TL;DR: Evidence that leads to the proposal that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response is discussed.
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Multipotent mesenchymal stromal cells and the innate immune system
TL;DR: It is important to study the crosstalk between MSCs and innate immunity, which ranges from the bone marrow niche to injured tissue, and to identify components of the innate immune system also have a key role.
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Mesenchymal Stem Cells: Mechanisms of Inflammation
Nora G. Singer,Arnold I. Caplan +1 more
TL;DR: A summary of ongoing clinical trials is provided to allow full comprehension of the range of diseases in which hMSC therapy may be beneficial and identification of gaps in knowledge about the mechanisms of action of therapeutic MSCs in disease.
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Mesenchymal Stem Cells: Time to Change the Name!
TL;DR: The name of MSCs should be changed to Medicinal Signaling Cells to more accurately reflect the fact that these cells home in on sites of injury or disease and secrete bioactive factors that are immunomodulatory and trophic (regenerative) meaning thatThese cells make therapeutic drugs in situ that are medicinal.
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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis
Tingfen Li,Yongmin Yan,Bingying Wang,Hui Qian,Xu Zhang,Li Shen,Mei Wang,Ying Zhou,Wei Zhu,Wei Li,Wenrong Xu +10 more
TL;DR: Results suggest that hucMSC-Ex could ameliorate CCl4-induced liver fibrosis by inhibiting EMT and protecting hepatocytes, which provides a novel approach for the treatment of fibrotic liver disease.
References
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Mesenchymal stem cells
TL;DR: The study of mesenchymal stem cells, whether isolated from embryos or adults, provides the basis for the emergence of a new therapeutic technology of self‐cell repair.
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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
TL;DR: Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.
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Human mesenchymal stem cells modulate allogeneic immune cell responses
TL;DR: Insight is offered into the interactions between allogeneic MSCs and immune cells and mechanisms likely involved with the in vivo MSC-mediated induction of tolerance that could be therapeutic for reduction of GVHD, rejection, and modulation of inflammation.
Related Papers (5)
A perivascular origin for mesenchymal stem cells in multiple human organs
Mihaela Crisan,Solomon Yap,Louis Casteilla,Louis Casteilla,Chien Wen Chen,Mirko Corselli,Tea Soon Park,Gabriella Andriolo,Bin Sun,Bo Zheng,Li Zhang,Cyrille Norotte,Pang-ning Teng,Jeremy Traas,Rebecca C. Schugar,Bridget M. Deasy,Stephen F. Badylak,Hans-Jörg Bühring,Jean-Paul Giacobino,Lorenza Lazzari,Johnny Huard,Bruno Péault +21 more