Dinghui Wu

TL;DR: Typical acute antibody response is induced during the SARS-CoV-2 infection and the serology testing provides important complementation to RNA test for pathogenic specific diagnosis and helpful information to evaluate the adapted immunity status of patient.

TL;DR: The results suggest that the prefusion trimer-stabilized SARS-CoV-2 S-protein from insect cells may offer a potential candidate strategy for the development of a recombinant COVID-19 vaccine.

TL;DR: Cryo-electron microscopy analyses indicate that the SARS-CoV-2 S trimer dominate in a unique conformation distinguished from the classic prefusion conformation of coronaviruses by the upper S1 region at lower position ~15 Å proximal to viral membrane.

TL;DR: In this article, the authors defined a quantitative antigenic map of neutralizing sites within SARS-CoV-2 RBD, and found that sites S2, S3 and S4 (new-found site) are conserved sites and determined as subimmunodominant sites, putatively due to their less accessibility.

TL;DR: By using antibodies obtained from convalescent COVID-19 patients, functional comparison of conserved antigenic sites at multiple aspects with each other, and even with SARS-CoV-2 unique antigenic Sites are succeeded, which promotes the cognition of process of humoral immune response to the conserved antibody sites.