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Shaowei Li
Researcher at Xiamen University
Publications - 184
Citations - 3144
Shaowei Li is an academic researcher from Xiamen University. The author has contributed to research in topics: Epitope & Capsid. The author has an hindex of 26, co-authored 151 publications receiving 2366 citations.
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Journal ArticleDOI
Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China
You-chun Wang,Huayuan Zhang,Ningshao Xia,Geng Peng,Hai-yun Lan,Hui Zhuang,Yong-hong Zhu,Shaowei Li,Ke-Gong Tian,Wen-jie Gu,Jing-Xiang Lin,Xing Wu,Hemin Li,Tim J. Harrison +13 more
TL;DR: Serum samples collected from pigs, cattle, and goats from various regions of China to determine whether they had been infected with hepatitis E virus (HEV) supported the hypothesis that sporadic hepatitis E in China is zoonotic.
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Virus-like particle-based human vaccines: quality assessment based on structural and functional properties
TL;DR: How the crucial quality attributes of VLP-based human vaccines against all three disease indications were assessed, controlled, and improved during bioprocessing through an array of structural and functional analyses is reviewed.
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Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus–Host Interaction
Shaowei Li,Xuhua Tang,Xuhua Tang,Jayaraman Seetharaman,Chunyan Yang,Ying Gu,Jun Zhang,Hailian Du,J. Wai Kuo Shih,Choy L. Hew,Choy L. Hew,J. Sivaraman,J. Sivaraman,Ningshao Xia +13 more
TL;DR: The crystal structure of the HEV capsid protein domain E2s, a protruding domain, is reported for the first time, together with functional studies to illustrate that this domain forms a tight homodimer and that this dimerization is essential for HEV–host interactions.
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Virus-mimetic nanovesicles as a versatile antigen-delivery system.
Pengfei Zhang,Yixin Chen,Yun Zeng,Chenguang Shen,Rui Li,Zhide Guo,Shaowei Li,Qingbing Zheng,Chengchao Chu,Zhantong Wang,Zizheng Zheng,Rui Tian,Shengxiang Ge,Xianzhong Zhang,Ningshao Xia,Gang Liu,Xiaoyuan Chen +16 more
TL;DR: VMVs are demonstrated to be straightforward, robust and tunable nanobiotechnology platforms for fabricating antigen delivery systems against a wide range of enveloped viruses.
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Structural basis for the neutralization and genotype specificity of hepatitis E virus
Xuhua Tang,Chunyan Yang,Ying Gu,Cuiling Song,Xiao Zhang,Yingbin Wang,Jun Zhang,Choy L. Hew,Shaowei Li,Ningshao Xia,J. Sivaraman +10 more
TL;DR: The complex crystal structure of 8C11 Fab with HEV E2s(I) domain is reported and the key residues that distinguish these two genotypes are revealed, which may lead to the development of antibody-based drugs for the specific treatment against HEV.