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Don C. Rockey
Researcher at Medical University of South Carolina
Publications - 8
Citations - 1575
Don C. Rockey is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Hepatic stellate cell & Cirrhosis. The author has an hindex of 7, co-authored 8 publications receiving 1257 citations. Previous affiliations of Don C. Rockey include University of Texas Southwestern Medical Center & Duke University.
Papers
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Journal ArticleDOI
Fibrosis — A Common Pathway to Organ Injury and Failure
TL;DR: The mechanisms underlying fibrosis and approaches to therapy are reviewed and fibrotic tissue becomes excessive, it can have diverse pathophysiological effects on a number of organ systems.
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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
Songling Liu,Richard T. Premont,Christopher D. Kontos,Shoukang Zhu,Don C. Rockey,Don C. Rockey +5 more
TL;DR: An important mechanism underlying impaired activity of eNOS in injured sinusoidal endothelial cells is defective phosphorylation of Akt caused by overexpression of GRK2 after injury, which leads to intrahepatic portal hypertension.
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Vascular pathobiology in chronic liver disease and cirrhosis – Current status and future directions
TL;DR: This review provides a detailed review of the current status and future direction of the basic biology of portal hypertension with a focus on the physiology, pathophysiology, and signaling of cells within the liver, as well as those in the mesenteric vascular circulation.
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G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.
TL;DR: A novel eNOS interactor, G-protein-coupled receptor (GPCR) kinase interactor-1 (GIT1), which plays an unexpected role in GPCR stimulated NO signaling, and this robust association was associated with stimulatory eNos phosphorylation, enzyme activation, and NO synthesis.
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Association of age-dependent liver injury and fibrosis with immune cell populations.
Bradley H. Collins,Zoie E. Holzknecht,Kellie A. Lynn,Gregory D. Sempowski,Catherine C. Smith,Songling Liu,William Parker,Don C. Rockey +7 more
TL;DR: The liver's response to injury is fibrosis, and when chronic, cirrhosis, and age is a critical factor impacting many immune‐mediated processes, potentially including the liver's wounding response to Injury.