Showing papers by "Donald A. Mahler published in 1992"
TL;DR: Dyspnea ratings influence and predict general health status to a greater extent than do physiologic measurements in symptomatic patients with COPD, and this consideration requires that health-care providers use available measuring tools in clinical practice to quantify symptoms, as well as overall health status.
175 citations
TL;DR: It is concluded that dyspnea ratings, maximal respiratory pressures, and lung function are separate factors or quantities that independently characterize the condition of patients with COPD.
Abstract: The purpose of this study was to demonstrate that clinical ratings of dyspnea and physiologic function are separate dimensions underlying the pathophysiology of chronic obstructive pulmonary disease (COPD). We used principal-components factor analysis to confirm these dimensions using data collected prospectively in 86 symptomatic patients with COPD. Three different instruments were used to rate dyspnea: a modified Medical Research Council (MRC) scale, the oxygen cost diagram (OCD), and the baseline dyspnea index (BDI). Measures of physiologic function included standard spirometric measures (forced vital capacity [FVC] and forced expiratory volume in one second [FEV1]) and maximal inspiratory (Pimax) and expiratory (Pemax) mouth pressures. Age of the 65 male and 21 female subjects was 62.9 ± 1.2 yr (mean ± SEM). All three clinical scales were significantly correlated with physiologic function (range of r values, 0.32 to 0.45; p < 0.05), except for the relationship between the MRC scale and Pemax (r = −0.1...
150 citations
TL;DR: The exercise intensity-dyspnea relationship appears to be the most appropriate stimulus-response relationship for quantifying dyspnea during exercise.
54 citations