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Dong Han
Researcher at Chinese PLA General Hospital
Publications - 46
Citations - 1481
Dong Han is an academic researcher from Chinese PLA General Hospital. The author has contributed to research in topics: Mesenchymal stem cell & Internal medicine. The author has an hindex of 18, co-authored 39 publications receiving 928 citations. Previous affiliations of Dong Han include Fourth Military Medical University.
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Journal ArticleDOI
Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition
Sai Ma,Jiangwei Chen,Jing Feng,Ran Zhang,Miaomiao Fan,Dong Han,Xiang Li,Congye Li,Jun Ren,Yabin Wang,Feng Cao +10 more
TL;DR: It is demonstrated that melatonin prevented atherosclerotic progression, at least in part, via inducing mitophagy and attenuating NLRP3 inflammasome activation, which was mediated by the Sirt3/FOXO3a/Parkin signaling pathway.
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Chitosan/silk fibroin modified nanofibrous patches with mesenchymal stem cells prevent heart remodeling post-myocardial infarction in rats.
Jiangwei Chen,Yingfei Zhan,Yabin Wang,Dong Han,Bo Tao,Zhenli Luo,Sai Ma,Qun Wang,Xiang Li,Li Fan,Congye Li,Hongbing Deng,Feng Cao,Feng Cao +13 more
TL;DR: It is suggested that CS/SF-modified nanofibrous patches promote the functional survival of engrafted AD-MSCs and restrain ventricular remodeling post-MI through attenuating myocardial fibrosis.
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SIRT1 Activation by Resveratrol Alleviates Cardiac Dysfunction via Mitochondrial Regulation in Diabetic Cardiomyopathy Mice
Sai Ma,Sai Ma,Jing Feng,Ran Zhang,Jiangwei Chen,Dong Han,Xiang Li,Bo Yang,Xiujuan Li,Miaomiao Fan,Congye Li,Zuhong Tian,Yabin Wang,Feng Cao,Feng Cao +14 more
TL;DR: Activation of SIRT1 by resveratrol ameliorated cardiac injuries in DCM through PGC-1α-mediated mitochondrial regulation, which may serve as a potential therapeutic target for DCM.
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The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a
Dong Han,Dong Han,Yongjun Wang,Yabin Wang,Xinchun Dai,Tingwen Zhou,Jiangwei Chen,Bo Tao,Jibin Zhang,Feng Cao,Feng Cao +10 more
TL;DR: The role of CircITCH is dissected and it is found that it acts as a natural sponge of miR-330-5p, thereby upregulating SIRT6, Survivin and SERCA2a to alleviate doxorubicin-induced cardiomyocyte injury and dysfunction and represents a novel therapeutic target for DOXIC.
Journal ArticleDOI
Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heart via the SIRT1 signaling pathway
Dong Han,Dong Han,Wei Huang,Xiang Li,Lei Gao,Tao Su,Xiujuan Li,Sai Ma,Tong Liu,Congye Li,Jiangwei Chen,Erhe Gao,Feng Cao,Feng Cao +13 more
TL;DR: The results demonstrated that melatonin promoted functional survival of AD‐MSCs in infarcted heart and provoked a synergetic effect with AD‐ MSCs to restore heart function and support the promise of melatonin as a novel strategy to improve MSC‐based therapy for IHD, possibly through SIRT1 signaling evocation.