D
Donna Heslin
Researcher at University of Toronto
Publications - 2
Citations - 1513
Donna Heslin is an academic researcher from University of Toronto. The author has contributed to research in topics: Interactivity & Leverage (statistics). The author has an hindex of 1, co-authored 1 publications receiving 1479 citations.
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Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
Christopher Janus,Jacqueline Pearson,JoAnne McLaurin,Paul M. Mathews,Ying Jiang,Stephen D. Schmidt,M. Azhar Chishti,Patrick Horne,Donna Heslin,Janet French,Howard T.J. Mount,Ralph A. Nixon,Marc Mercken,Catherine Bergeron,Catherine Bergeron,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop,David Westaway +18 more
TL;DR: Aβ immunization reduces both deposition of cerebral fibrillar Aβ and cognitive dysfunction in the TgCRND8 murine model of Alzheimer's disease without, however, altering total levels of Aβ in the brain, which implies that either a ∼50% reduction in dense-cored Aβ plaques is sufficient to affect cognition, or that vaccination may modulate the activity/abundance of a small subpopulation of especially toxic Aβ species.
Journal ArticleDOI
The online promotion of university entrepreneurship centres
Donna Heslin,Creso M. Sá +1 more