Doreen Hooi

TL;DR: The ability of compounds selected from the optimal activity range to modulate mitogen-driven human peripheral blood mononuclear cell proliferation and LPS-induced TNF-alpha secretion indicates the suitability of these compounds for further investigation in relation to their molecular mechanisms of action in TNF -alpha driven immunological diseases, particularly autoimmune diseases.

TL;DR: The comparative effects of two chemically distinct and endobronchially detectable QSSM, N-(3-oxodododecanoyl)-l-homoserine lactone and 2-heptyl-3-hydroxy-4 (1H)-quinolone or the Pseudomonas quinolone signal (PQS), on human leukocytes exposed to a series of stimuli designed to detect differential immunological activity in vitro are determined.

TL;DR: The first clinical trial of experimental hookworm infection in people with allergic asthma is reported, and it is reported that hookworms infection protects against asthma.

TL;DR: It is demonstrated that the QSSM N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) from P. aeruginosa blocks proliferation and induces apoptosis in human BC cell lines, supporting the notion of OdDHL as a bioactive molecule in eukaryotic systems and a paradigm for a novel class of antiproliferative compounds.

TL;DR: It is necessary to establish whether experimental hookworm infection might exacerbate airway responsiveness during larval lung migration before testing this hypothesis in a clinical trial in asthma.