D
Dorit Ben-Shachar
Researcher at Rappaport Faculty of Medicine
Publications - 108
Citations - 8650
Dorit Ben-Shachar is an academic researcher from Rappaport Faculty of Medicine. The author has contributed to research in topics: Dopamine & Substantia nigra. The author has an hindex of 49, co-authored 106 publications receiving 8071 citations. Previous affiliations of Dorit Ben-Shachar include Weizmann Institute of Science & Technion – Israel Institute of Technology.
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Journal ArticleDOI
Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases
TL;DR: Some of the experimental evidence indicating a role of disturbed iron metabolism as a cause of the neurodegenerative disorder Parkinson's disease and possibly other neuro degenerative disorders such as Alzheimer's disease are presented.
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Therapeutic Efficacy of Right Prefrontal Slow Repetitive Transcranial Magnetic Stimulation in Major Depression: A Double-blind Controlled Study
Ehud Klein,Isabella Kreinin,Andrei Chistyakov,Danny Koren,Lilly Mecz,Sarah Marmur,Dorit Ben-Shachar,Moshe Feinsod +7 more
TL;DR: Evidence is provided for the short-term efficacy of slow repetitive TMS in patients with recurrent major depression as compared with electroconvulsive therapy as well as the long-term outcome of this treatment in major depression and possibly other psychiatric disorders.
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Iron-Melanin Complex in Substantia Nigra of Parkinsonian Brains: An X-Ray Microanalysis
Kurt A. Jellinger,E. Kienzl,G. Rumpelmair,Peter Riederer,H. Stachelberger,Dorit Ben-Shachar,Moussa B.H. Youdim +6 more
TL;DR: Findings support the assumption that an iron‐melanin interaction contributes significantly to dopaminergic neurodegeneration in PD and PD plus AD.
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The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons.
TL;DR: The ability of iron chelators to retard dopaminergic neurodegeneration in the substantia nigra may indicate a new therapeutic strategy in the treatment of Parkinson's disease.
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Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration?
TL;DR: The excessive accumulation of free iron in the SN and “melanintrap'’ could be the trigger for accelerated cell death and Parkinsonism.