Dorte Glintborg

TL;DR: Evidence is provided for a functional impairment in mitochondrial respiration and increased amount of type 2X fibers in muscle oftype 2 diabetic patients that may contribute to the development of type 1 diabetes in humans with obesity.

TL;DR: It is demonstrated that impaired insulin-stimulated total, oxidative and nonoxidative glucose disposal in PCOS patients are associated with a consistent downregulation of OXPHOS gene expression using GSEA and GenMAPP analysis, which supports the hypothesis of an early association between insulin resistance and impaired mitochondrial oxidative metabolism.

TL;DR: A comprehensive overview of the pathophysiology and multiple endocrine disturbances of hirsutism and PCOS is given.

TL;DR: The event rate of CVD including hypertension and dyslipidemia was higher in PCOS compared to controls, and the risk of developing CVD must be considered even in young women with PCOS.

TL;DR: The ability of pioglitazone to enhance insulin sensitivity involves improved signaling through Akt and AS160, and the data provide correlative evidence that hyperandrogenism in PCOS may contribute to insulin resistance.