D
Douglas S Cortez
Researcher at United States Department of the Army
Publications - 12
Citations - 479
Douglas S Cortez is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Resuscitation & Partial thromboplastin time. The author has an hindex of 10, co-authored 12 publications receiving 462 citations.
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Journal ArticleDOI
Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs.
TL;DR: Hypothermia inhibited clotting times and clotting rate, whereas hemorrhage impaired clot strength, and only TEG differentiated mechanism related to clotting abnormalities, and thus may allow focused treatment of clotting alterations associated with hypothermia and hemorrhagic shock.
Journal ArticleDOI
Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries.
Harold G. Klemcke,Ángel V. Delgado,John B. Holcomb,Kathy L. Ryan,Allen P. Burke,Rodolpho DeGuzman,Michael R. Scherer,Douglas S Cortez,John M. Uscilowicz,Joseph M Macaitis,Jason Bliss,Jennifer Wojtaszczyk,Suzanne Christensen,Heather Currier,Anthony E. Pusateri +14 more
TL;DR: These data indicate an inability of rFVIIa at these doses to reduce blood loss, or to increase survival time or percent survival in this pig model, and absence of DIC provides evidence for safe use of r FVIIa under conditions specific to this study.
Journal ArticleDOI
A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury.
Ángel V. Delgado,Bijan S. Kheirabadi,Todd M. Fruchterman,Michael R. Scherer,Douglas S Cortez,Charles E. Wade,Michael A. Dubick,John B. Holcomb +7 more
TL;DR: FP with packing effectively controlled coagulopathic bleeding and prevented death in a model of grade V liver injury in which HP alone (standard of care) was ineffective.
Earlier Debridement and Antibiotic Administration Decrease Infection
TL;DR: It was concluded that early debridement in combination with local delivery of antibiotics of contaminated defects may reduce infections.
Journal ArticleDOI
Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metabolic responses, and coagulation in pigs after severe hemorrhagic shock
TL;DR: NS may be inferior to LR in resuscitation due to its vasodilator effects and the risks of metabolic acidosis and hyperkalemia.