D
Doychin N. Angelov
Researcher at University of Cologne
Publications - 24
Citations - 2052
Doychin N. Angelov is an academic researcher from University of Cologne. The author has contributed to research in topics: Facial nerve & Reinnervation. The author has an hindex of 20, co-authored 21 publications receiving 1948 citations.
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Journal ArticleDOI
Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis
Doychin N. Angelov,Stefan Waibel,Orlando Guntinas-Lichius,Mithra Lenzen,Wolfram F. Neiss,Toma L. Tomov,Eti Yoles,Jonathan Kipnis,Hadas Schori,A. Reuter,Albert C. Ludolph,Michal Schwartz +11 more
TL;DR: The studies show that vaccination significantly improved motor activity and suggest that Cop-1 vaccination boosts the local immune response needed to combat destructive self-compounds associated with motor neuron death.
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Olfactory ensheathing glia and Schwann cells: two of a kind?
TL;DR: The present review summarizes recent data on the in vitro and in vivo properties of OECs and critically compares the analogies and differences in the biology of both cell types relevant in the above-mentioned context.
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Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses
Orlando Guntinas-Lichius,Andrey Irintchev,Michael Streppel,Mithra Lenzen,Maria Grosheva,Konstantin Wewetzer,Wolfram F. Neiss,Doychin N. Angelov +7 more
TL;DR: It was found that motor end‐plates with morphological signs of multiple innervation were much more frequent in reinnervated muscles of rats that did not recover after injury than in animals with good functional performance, raising hopes that clinically feasible and effective therapies could be soon designed and tested.
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Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion.
Michael Streppel,N. Azzolin,S. Dohm,Orlando Guntinas-Lichius,Carola A. Haas,Claudia Grothe,Andrea Wevers,Wolfram F. Neiss,Doychin N. Angelov +8 more
TL;DR: This first report on improved quality of reinnervation by antibody‐therapy implies that, in rats, the post‐transectional collateral axonal branching can be reduced without obvious harmful effects on neuronal survival and axonal elongation.
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Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve
Doychin N. Angelov,Wolfram F. Neiss,Michael Streppel,Jonas Andermahr,K Mader,Eberhard Stennert +5 more
TL;DR: Facial-facial anastomosis, i.e., suture of transected facial nerve, was performed in adult Wistar rats and nimodipine reduced the polyneuronal innervation of the target muscles.