W
Wolfram F. Neiss
Researcher at University of Cologne
Publications - 144
Citations - 4177
Wolfram F. Neiss is an academic researcher from University of Cologne. The author has contributed to research in topics: Reinnervation & Facial nerve. The author has an hindex of 36, co-authored 141 publications receiving 3853 citations. Previous affiliations of Wolfram F. Neiss include University of Würzburg.
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Journal ArticleDOI
Therapeutic vaccine for acute and chronic motor neuron diseases: Implications for amyotrophic lateral sclerosis
Doychin N. Angelov,Stefan Waibel,Orlando Guntinas-Lichius,Mithra Lenzen,Wolfram F. Neiss,Toma L. Tomov,Eti Yoles,Jonathan Kipnis,Hadas Schori,A. Reuter,Albert C. Ludolph,Michal Schwartz +11 more
TL;DR: The studies show that vaccination significantly improved motor activity and suggest that Cop-1 vaccination boosts the local immune response needed to combat destructive self-compounds associated with motor neuron death.
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Factors limiting motor recovery after facial nerve transection in the rat: combined structural and functional analyses
Orlando Guntinas-Lichius,Andrey Irintchev,Michael Streppel,Mithra Lenzen,Maria Grosheva,Konstantin Wewetzer,Wolfram F. Neiss,Doychin N. Angelov +7 more
TL;DR: It was found that motor end‐plates with morphological signs of multiple innervation were much more frequent in reinnervated muscles of rats that did not recover after injury than in animals with good functional performance, raising hopes that clinically feasible and effective therapies could be soon designed and tested.
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Focal application of neutralizing antibodies to soluble neurotrophic factors reduces collateral axonal branching after peripheral nerve lesion.
Michael Streppel,N. Azzolin,S. Dohm,Orlando Guntinas-Lichius,Carola A. Haas,Claudia Grothe,Andrea Wevers,Wolfram F. Neiss,Doychin N. Angelov +8 more
TL;DR: This first report on improved quality of reinnervation by antibody‐therapy implies that, in rats, the post‐transectional collateral axonal branching can be reduced without obvious harmful effects on neuronal survival and axonal elongation.
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Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve
Doychin N. Angelov,Wolfram F. Neiss,Michael Streppel,Jonas Andermahr,K Mader,Eberhard Stennert +5 more
TL;DR: Facial-facial anastomosis, i.e., suture of transected facial nerve, was performed in adult Wistar rats and nimodipine reduced the polyneuronal innervation of the target muscles.
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Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair.
Antoni Valero-Cabré,Konstantin Tsironis,Emmanouil Skouras,Gabriele Perego,Xavier Navarro,Wolfram F. Neiss +5 more
TL;DR: Considering the higher CMAP amplitude and lower number of neurons with multiple projections, PLC nerve conduits seem superior to SIL tubes and a suitable alternative to autografts for the repair of long gaps.