Draginja Mrvoš-Sermek

TL;DR: The multistep synthesis of a series of new substituted-benzothiazoles as hydrochloride or quaternary salts exerted a different inhibitory effect, depended on concentration and type of the cells.

TL;DR: 6-Chloro derivative of 2,3-di-O-benzyl-5, 6-epoxy- and 5,6-isopropylidene-l-ascorbic acid showed the best cytostatic effects against all tested malignant tumor cells (IC50: approximately 18 microM).

TL;DR: In this article, the influence of steric requirements of the ligands on the distortion of the coordination polyhedra accompanied with the relative strength of Hg...N contacts is considered, revealing strong influence of hydrogen bonds on their relative strengths as well as crystal packing requirements of a ligand.

TL;DR: Of all the compounds of this series, spirobipyridopyran (1) inhibited specifically the growth of human melanoma (HBL) cells but not the grow of normal fibroblasts (WI38), and Indolinospirobenzopyrans showed significant cytostatic activities against all tumor cell lines.

TL;DR: The novel fluorinated and iodinated purine derivatives, and particularly 9a and 9b, appear to demonstrate sufficient cytostatic potency and selectivity to justify further evaluation of their potential.