Showing papers by "Drake S. Eggleston published in 2000"
182 citations
TL;DR: The three-dimensional high-resolution structure of the RNaseP protein from Staphylococcus aureus is determined by nuclear magnetic resonance (NMR) spectroscopy in solution and it is revealed that this protein has an alphabeta-fold, similar to the ribonucleoprotein domain, and a conserved arginine-rich motif does not bind single-stranded RNA.
101 citations
TL;DR: One of four stereoisomeric dipeptides incorporating these novel amino acids was found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, suggesting analogous stereochemistry of the natural product.
31 citations
TL;DR: In this article, the synthesis of synthetic analogues of the microbial metabolite SB-219383 with defined stereochemistry was described, and four stereoisomeric dipeptides incorporating these novel amino acids were found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase.
Abstract: Synthetic analogues of the microbial metabolite SB-219383 have been synthesised with defined stereochemistry. Densely functionalised hydroxylamine containing amino acids were prepared by the addition of a glycine anion equivalent to sugar-derived cyclic nitrones. One of four stereoisomeric dipeptides incorporating these novel amino acids was found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, suggesting analogous stereochemistry of the natural product.