D
Duane D. Winkler
Researcher at University of Texas at Dallas
Publications - 28
Citations - 1431
Duane D. Winkler is an academic researcher from University of Texas at Dallas. The author has contributed to research in topics: Chromatin & Nucleosome. The author has an hindex of 14, co-authored 27 publications receiving 1257 citations. Previous affiliations of Duane D. Winkler include Colorado State University & University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
The Histone Chaperone FACT: Structural Insights and Mechanisms for Nucleosome Reorganization
Duane D. Winkler,Karolin Luger +1 more
TL;DR: The structural and biophysical basis for FACT-mediated nucleosome reorganization and up-to-date models for Fact function are reviewed and discussed.
Journal ArticleDOI
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
TL;DR: It is demonstrated that the accumulation of disulfide cross-linked, detergent-insoluble, aggregates of mutant SOD1 occurs primarily in the later stages of the disease, concurrent with the appearance of rapidly progressing symptoms.
Journal ArticleDOI
Histone Chaperone FACT Coordinates Nucleosome Interaction through Multiple Synergistic Binding Events
TL;DR: It is demonstrated that FACT binds histones, DNA, and intact nucleosomes at nanomolar concentrations and is proposed that the conserved acidic C-terminal domain of the FACT subunit Spt16 actively displaces nucleosomal DNA to provide access to the histone octamer.
Journal ArticleDOI
Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS
Magdalena I. Ivanova,Stuart A. Sievers,Stuart A. Sievers,E.L. Guenther,Lisa M. Johnson,Duane D. Winkler,Duane D. Winkler,Ahmad Galaleldeen,Ahmad Galaleldeen,Michael R. Sawaya,P. John Hart,David Eisenberg +11 more
TL;DR: The hypothesis is that improper protein maturation and incompletely folded states that render these aggregation-prone segments available for interaction offer a common molecular pathway for sALS and fALS.
Journal ArticleDOI
Evidence for monomeric actin function in INO80 chromatin remodeling.
TL;DR: This work identifies an actin mutation in subdomain 2 affecting in vivo nuclear functions and reducing the chromatin remodeling activity of the INO80 complex in vitro, and establishes an evolutionarily conserved function of nuclear actin in its monomeric form and suggests thatnuclear actin can utilize a fundamentally distinct mechanism from that of cytoplasmic actin.