E
E. A. Romanovskaya-Romanko
Researcher at Russian Academy
Publications - 17
Citations - 148
E. A. Romanovskaya-Romanko is an academic researcher from Russian Academy. The author has contributed to research in topics: Virus & Medicine. The author has an hindex of 4, co-authored 9 publications receiving 124 citations.
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Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.
Brigitte M. Krenn,Andrej Egorov,E. A. Romanovskaya-Romanko,Markus Wolschek,Sabine Nakowitsch,Tanja Ruthsatz,Bettina Kiefmann,Alexander Morokutti,Johannes Humer,Janina Geiler,Jindrich Cinatl,Martin Michaelis,Nina Wressnigg,Sanda Sturlan,Boris Ferko,Oleg V. Batishchev,A. V. Indenbom,Rong Zhu,Markus Kastner,Peter Hinterdorfer,Oleg I. Kiselev,Thomas Muster,Julia Romanova +22 more
TL;DR: The finding suggests that an efficient intranasal vaccination with a live attenuated H5N1 virus may require a certain level of pH and temperature stability of HA in order to achieve an optimal virus uptake by the nasal epithelial cells and induce a sufficient immune response.
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Broad-spectrum anti-tumor and anti-metastatic DNA vaccine based on p62-encoding vector
Franco M. Venanzi,Victor Shifrin,Michael Y. Sherman,Vladimir L. Gabai,Oleg I. Kiselev,Andrey Komissarov,Grudinin Mp,Maria Shartukova,E. A. Romanovskaya-Romanko,Yuri Kudryavets,Natalya Bezdenezhnykh,Oleksandra Lykhova,Nadiia Semesyuk,Antonio Concetti,Anatoly F. Tsyb,Marina Filimonova,Victoria Makarchuk,Raisa Yakubovsky,Andrey Chursov,Vita Shcherbinina,Alexander M. Shneider +20 more
TL;DR: It is reported that the transformation of normal human mammary epithelial cells with diverse oncogenes (RAS, PIK3CA and Her2) causes marked accumulation of p62, and a p62-encoding vector constitute(s) a novel, effective broad-spectrum antitumor and anti-metastatic vaccine feasible for further development and clinical trials.
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Antimycotic-Antibiotic Amphotericin B Promotes Influenza Virus Replication in Cell Culture
Elisabeth Roethl,Manuela Gassner,Brigitte M. Krenn,E. A. Romanovskaya-Romanko,Helena Seper,Julia Romanova,Sabine Nakowitsch,Sanda Sturlan,Markus Wolschek,Alexej Sirotkin,Oleg I. Kiselev,Thomas Muster,Andrej Egorov +12 more
TL;DR: The results indicate that the use of AmB may facilitate influenza virus isolation and production in Vero cells and the AmB-enhancing effect seemed to be solely due to the viral hemagglutinin function.
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Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2
Igor V. Krasilnikov,Aleksandr V Kudriavtsev,Anna V Vakhrusheva,M. E. Frolova,A. Ivanov,Marina Stukova,E. A. Romanovskaya-Romanko,Kirill Vasilyev,Nataliya V. Mushenkova,A. A. Isaev +9 more
TL;DR: The development of a SARS-CoV-2 subunit vaccine candidate based on RBD and SD1 domains of the spike (S) protein fused to a human IgG1 Fc fragment is reported, and it is demonstrated that two immunizations of mice with Betuvax-Cov-2 elicited high titers of RBD-specific antibodies.
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Ebola hemorrhagic fever: Properties of the pathogen and development of vaccines and chemotherapeutic agents
Oleg I. Kiselev,Andrey V. Vasin,M. P. Shevyryova,E. G Deeva,K. V. Sivak,Vladimir V. Egorov,Vladimir B. Tsvetkov,A. Yu. Egorov,E. A. Romanovskaya-Romanko,L. A. Stepanova,Andrey Komissarov,L. M. Tsybalova,G. M. Ignatjev +12 more
TL;DR: Ebola hemorrhagic fever (EHF) epidemic currently ongoing in West Africa seems to be the worst EHF epidemic outbreak caused by Ebola virus Zaire since 1976 as regards its extremely large scale and rapid spread in the population.