E
E. Claire Dees
Researcher at University of North Carolina at Chapel Hill
Publications - 101
Citations - 7659
E. Claire Dees is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 37, co-authored 80 publications receiving 7056 citations. Previous affiliations of E. Claire Dees include University of Wisconsin-Madison & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Lisa A. Carey,E. Claire Dees,Lynda R. Sawyer,Lisa Gatti,Dominic T. Moore,Frances A. Collichio,David W. Ollila,Carolyn I. Sartor,Mark L. Graham,Charles M. Perou +9 more
TL;DR: Basal-like and HER2+/ER− subtypes are more sensitive to anthracycline-based neoadjuvant chemotherapy than luminal breast cancers and could be explained by a higher likelihood of relapse in patients in whom pathologic complete response was not achieved.
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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas
Howard A. Burris,Herbert Hurwitz,E. Claire Dees,Afshin Dowlati,Kimberly L. Blackwell,Bert H. O'Neil,Paul K. Marcom,Matthew J. Ellis,Beth Overmoyer,Suzanne F. Jones,Jennifer Harris,Deborah A. Smith,Kevin M. Koch,Andrew G. Stead,Steve Mangum,Neil L. Spector +15 more
TL;DR: Lapatinib was well tolerated at doses ranging from 500 to 1,600 mg once daily and clinical activity was observed in heavily pretreated patients with ErbB1-expressing and/or ErbbB2-overexpressing metastatic cancers, including four PRs in patients with trastuzumab-resistant breast cancers and prolonged stable disease in 10 patients.
Journal Article
The Proteasome as a Target for Cancer Therapy
TL;DR: Ongoing preclinical evaluations of the mechanisms that underlie the antitumor effects of proteasome inhibitors, and clinical trials in a variety of tumor types, will allow additional refinement of the role these agents will play in cancer therapy.
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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies
Neil L. Spector,Wenle Xia,Howard A. Burris,Herbert Hurwitz,E. Claire Dees,Afshin Dowlati,Bert H. O'Neil,Beth Overmoyer,Paul K. Marcom,Kimberly L. Blackwell,Deborah A. Smith,Kevin M. Koch,Andrew G. Stead,Steven Mangum,Matthew J. Ellis,Leihua Liu,Albert Man,Troy Bremer,Jennifer Harris,Sarah S. Bacus +19 more
TL;DR: Preliminary evidence of biologic and clinical activity in ErbB1 and/or Erb B2-overexpressing tumors is exhibited, however, the limited sample size of this study and the variability of the biologic endpoints suggest that further work is needed to prioritize biomarkers for disease-directed studies, and underscores the need for improved trial design strategies in early clinical studies of targeted agents.
Journal ArticleDOI
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
Robert Z. Orlowski,Robert Z. Orlowski,Peter M. Voorhees,Peter M. Voorhees,Reynaldo Garcia,Reynaldo Garcia,Melissa D. Hall,Melissa D. Hall,Fred J. Kudrik,Fred J. Kudrik,Tammy Allred,Tammy Allred,Anandhi R. Johri,Anandhi R. Johri,Paul Jones,Paul Jones,Anastasia Ivanova,Anastasia Ivanova,Hendrik W. van Deventer,Hendrik W. van Deventer,Don A. Gabriel,Don A. Gabriel,Thomas C. Shea,Thomas C. Shea,Beverly S. Mitchell,Beverly S. Mitchell,Julian Adams,Julian Adams,Dixie Lee Esseltine,Dixie Lee Esseltine,Elizabeth G. Trehu,Elizabeth G. Trehu,Marie Green,Marie Green,Mary Jo Lehman,Mary Jo Lehman,Susan Natoli,Susan Natoli,Jason M. Collins,Jason M. Collins,Celeste Lindley,Celeste Lindley,E. Claire Dees,E. Claire Dees +43 more
TL;DR: Bortezomib/PegLD was safely administered in this study with promising antitumor activity, supporting further testing of this regimen and pharmacokinetic and pharmacodynamic studies did not find significant drug interactions between these agents.