E
E Levi
Researcher at Howard Hughes Medical Institute
Publications - 1
Citations - 676
E Levi is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & Growth factor. The author has an hindex of 1, co-authored 1 publications receiving 671 citations.
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Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.
TL;DR: A simple assay based on a genetically engineered soluble form of murine FGF receptor 1 tagged with placental alkaline phosphatase showed that FGF-receptor binding has an absolute requirement for heparin and facilitated FGF dimerization, a property that may be important for receptor activation.