E
E. N. Lebedenko
Researcher at Russian Academy of Sciences
Publications - 22
Citations - 783
E. N. Lebedenko is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Gene & Restriction enzyme. The author has an hindex of 12, co-authored 21 publications receiving 717 citations.
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Design of multivalent complexes using the barnase·barstar module
TL;DR: It is shown that the anticipated gain in avidity from monomer to dimer to trimer is obtained and that favorable tumor targeting properties are achieved and many permutations of engineered multispecific fusion proteins become accessible with this technology of quasi-covalent heterodimers.
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Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design.
Sergey M. Deyev,E. N. Lebedenko +1 more
TL;DR: Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy.
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Modern Technologies for Creating Synthetic Antibodies for Clinical application.
Sergey M. Deyev,E. N. Lebedenko +1 more
TL;DR: This review focuses on up-to-date methods of antibody engineering for diagnosing and treating various diseases, particularly on new technologies meant to refine the effector functions of therapeutic antibodies.
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Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering
Sergey M. Deyev,E. N. Lebedenko,Lada E. Petrovskaya,Dmitry A. Dolgikh,Alexander G. Gabibov,Mikhail P. Kirpichnikov +5 more
TL;DR: Modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases are covered.
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Method of artificial DNA splicing by directed ligation (SDL).
TL;DR: An approach to directed genetic recombination in vitro has been devised, which allows for joining together, in a predetermined way, a series of DNA segments to give a precisely spliced polynucleotide sequence (DNA splicing by directed ligation, SDL).