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Sergey M. Deyev

Researcher at Russian Academy of Sciences

Publications -  235
Citations -  4239

Sergey M. Deyev is an academic researcher from Russian Academy of Sciences. The author has contributed to research in topics: Barnase & Medicine. The author has an hindex of 30, co-authored 183 publications receiving 3061 citations. Previous affiliations of Sergey M. Deyev include Nizhny Novgorod State Technical University & Engelhardt Institute of Molecular Biology.

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Journal ArticleDOI

Design of multivalent complexes using the barnase·barstar module

Sergey M. Deyev, +4 more
- 23 Nov 2003 - 
TL;DR: It is shown that the anticipated gain in avidity from monomer to dimer to trimer is obtained and that favorable tumor targeting properties are achieved and many permutations of engineered multispecific fusion proteins become accessible with this technology of quasi-covalent heterodimers.
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Multivalency: the hallmark of antibodies used for optimization of tumor targeting by design.

Sergey M. Deyev, +1 more
- 01 Sep 2008 - 
TL;DR: Different multimerization strategies used now in antibody engineering make it possible to optimize biodistribution and tumor targeting of recombinant antibody constructs for cancer diagnostics and therapy.
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Targeting cancer cells by using an antireceptor antibody-photosensitizer fusion protein

Ekaterina O. Serebrovskaya, +5 more
- 09 Jun 2009 - 
TL;DR: 4D5scFv-KillerRed showed fine targeting properties and efficiently killed p185HER-2-ECD-expressing cancer cells upon light irradiation and showed a remarkable additive effect with the commonly used antitumor agent cisplatin, further demonstrating the potential of the approach.
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Biocomputing based on particle disassembly

Maxim P. Nikitin, +3 more
- 01 Sep 2014 - 
TL;DR: It is shown that almost any type of nanoparticle or microparticle can be transformed into autonomous biocomputing structures that are capable of implementing a functionally complete set of Boolean logic gates and binding to a target as result of a computation.
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Neuroblastoma Origin and Therapeutic Targets for Immunotherapy

I. V. Kholodenko, +5 more
- 11 Jul 2018 - 
TL;DR: Development of effective and safe GD2-targeted immunotherapies and analysis of other potential molecular targets for the treatment of neuroblastoma represents an important and topical task.