E
E. R Samuels
Researcher at University of Nottingham
Publications - 2
Citations - 1021
E. R Samuels is an academic researcher from University of Nottingham. The author has contributed to research in topics: Locus coeruleus & Laterodorsal tegmental nucleus. The author has an hindex of 2, co-authored 2 publications receiving 857 citations.
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Journal ArticleDOI
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation.
E. R Samuels,E Szabadi +1 more
TL;DR: The locus coeruleus is the major noradrenergic nucleus of the brain, giving rise to fibres innervating extensive areas throughout the neuraxis, resulting in complex patterns of neuronal activity throughout the brain.
Journal ArticleDOI
Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part II: Physiological and Pharmacological Manipulations and Pathological Alterations of Locus Coeruleus Activity in Humans
E. R Samuels,E Szabadi +1 more
TL;DR: In general, physiological manipulations and the administration of stimulant drugs, α2-adrenoceptor antagonists and noradrenaline uptake inhibitors increase LC activity and thus cause heightened arousal and activation of the sympathetic nervous system, and theAdministration of sedative drugs, including α 2-adRenoceptor agonists, and pathological changes in LC function in neurodegenerative disorders and ageing reduceLC activity and result in sedation andactivation of the parasympathetic nervous system.