E
E Van Schaftingen
Researcher at Université catholique de Louvain
Publications - 63
Citations - 4588
E Van Schaftingen is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Fructose & Glucokinase. The author has an hindex of 36, co-authored 63 publications receiving 4410 citations. Previous affiliations of E Van Schaftingen include International Institute of Minnesota & Catholic University of Leuven.
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Journal ArticleDOI
Fructose 2,6-bisphosphate 2 Years After its Discovery
TL;DR: Fru-2,6-P2 is not an intermediary metabolite of glycolysis, but its most potent regulator and its potential role in the control of metabolism in various organisms is delineated.
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Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)
Gert Matthijs,Els Schollen,Els Pardon,Maria Veiga-da-Cunha,Jacques Jaeken,Jean-Jacques Cassiman,E Van Schaftingen +6 more
TL;DR: The results give conclusive support to the biochemical finding that the phosphomannomutase deficiency is the basis for CDG1.
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Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.
TL;DR: The low-molecular-weight stimulator of phosphofructokinase has been purified from rat liver and is tentatively identified as fructose 2,6-bisphosphate.
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Inhibition of fructose-1,6-bisphosphatase by fructose 2,6-biphosphate
TL;DR: Fructose 2,6-bisphosphate, a known powerful stimulator of phosphofructokinase, was found to inhibit, at micromolar concentrations, liver and muscle fructose-1-6-biphosphate (D-fructose-1, 6-bisPhosphate 1-phosphohydrolase, EC 3.3.1.11).
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Short-term control of glucokinase activity: role of a regulatory protein.
TL;DR: Unlike other hexokinases, glucokinase is not inhibited by micromolar (physiological) concentrations of glucose 6‐phosphate but by a regulatory protein that transduces the effect of fructose 6‐ phosphate and of fructose 1‐ph phosphate.